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Tclin
GHSR
Growth hormone secretagogue receptor type 1

Protein Summary
Description
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241256
  • ENSP00000241256
  • ENSG00000121853
  • ENST00000427970
  • ENSP00000395344

Symbol
  • GHDP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.87
gene perturbation
0.74
ligand (chemical)
0.66
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.41   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.41   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1263
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (211)
GHRL
Tbio
Novelty:  0.00017827
Score:  0.989
Data Source:  Reactome,STRINGDB
MLN
Tbio
Novelty:  0.0010297
Score:  0.968
Data Source:  STRINGDB
NMU
Tbio
Novelty:  0.00326109
Score:  0.966
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.961
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.959
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.958
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.957
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.95
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.938
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
90.8
TNF-related apoptosis-inducing ligand measurement
1
1
1
84.9
IGF-1 measurement
1
4
4
83.3
aspartate aminotransferase measurement
1
1
1
79.7
blood protein measurement
1
1
1
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
90.8
TNF-related apoptosis-inducing ligand measurement
1
84.9
IGF-1 measurement
4
83.3
aspartate aminotransferase measurement
1
79.7
blood protein measurement
1
77.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone secretagogue receptor
VGNC:1825
460851
Macaque
growth hormone secretagogue receptor
694587
Mouse
MGI:2441906
208188
Rat
RGD:621397
84022
Dog
growth hormone secretagogue receptor
VGNC:41210
100101479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone secretagogue receptor
Macaque
growth hormone secretagogue receptor
Mouse
Rat
Dog
growth hormone secretagogue receptor
Publication Statistics
PubMed Score 417.41
PubMed score by year
PubTator Score 467.84
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title