Tclin GHSR Growth hormone secretagogue receptor type 1

Protein Summary

Description

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q92847
• Q14D12
• Q6ISR8
• Q92848
• Q96RJ7
• GHS-R

Gene Name

• GHSR

Ensembl ID

• ENST00000241256
• ENSP00000241256
• ENSG00000121853
• ENST00000427970
• ENSP00000395344

Symbol

• GHDP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
biological term	0.87
gene perturbation	0.74
ligand (chemical)	0.66
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Growth Hormone Secretagogue Receptor Type 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Ghrelin Receptor / Growth Hormone Secretagogue Receptor Type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.37   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.37   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1297

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3