Tbio KIFAP3 Kinesin-associated protein 3

Protein Summary

Description

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q92845
• B1AKU4
• B1AKU5
• B2RDL1
• B7Z8A3
• F5H591
• Q8NHU7
• Q9H416
• KAP-3

Gene Name

• KIFAP3

Ensembl ID

• ENST00000361580
• ENSP00000354560
• ENSG00000075945
• ENST00000367765
• ENSP00000356739
• ENST00000367767
• ENSP00000356741
• ENST00000538366
• ENSP00000444622

Symbol

• KIF3AP
• SMAP
• FLA3
• KAP3
• SMAP
• KAP-1
• KAP-3
• Smg-GDS
• dJ190I16.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.86
virus perturbation	0.85
histone modification site profile	0.79
tissue sample	0.68
transcription factor perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (238)

Explore Interacting Targets

1 – 10 of 238

• See Interactions on String-DB

KIF3A

Tbio

Novelty:  0.00555124

p_int:  1

Score:  0.993

Data Source:  BioPlex,Reactome,STRINGDB

KIF3B

Tbio

Novelty:  0.01877656

p_int:  0.999999988

p_ni:  2e-9

p_wrong:  1.1e-8

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

KIF3C

Tbio

Novelty:  0.0512445

p_int:  0.999999952

p_ni:  2e-9

p_wrong:  4.7e-8

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

RAP1A

Tchem

Family:  Enzyme

Novelty:  0.00375413

p_int:  0.999969567

p_ni:  0.000030417

p_wrong:  1.7e-8

Score:  0.189

Data Source:  BioPlex,STRINGDB

CCNY

Tbio

Novelty:  0.01400663

p_int:  0.99833167

p_ni:  0.001660896

p_wrong:  0.000007435

Score:  0.175

Data Source:  BioPlex,STRINGDB

ERICH5

Tdark

Novelty:  5.57504212

p_int:  0.997405757

p_ni:  0.002594243

Data Source:  BioPlex

SRC

Tclin

Family:  Kinase

Novelty:  0.00008479

p_int:  0.993437152

p_ni:  0.006562844

p_wrong:  4e-9

Score:  0.495

Data Source:  BioPlex,STRINGDB

GTF2IRD1

Tbio

Family:  TF

Novelty:  0.01858027

p_int:  0.972914117

p_ni:  0.027075119

p_wrong:  0.000010764

Score:  0.175

Data Source:  BioPlex,STRINGDB

PAK2

Tchem

Family:  Kinase

Novelty:  0.0149123

p_int:  0.970128886

p_ni:  0.029855788

p_wrong:  0.000015326

Score:  0.182

Data Source:  BioPlex,STRINGDB

VAMP3

Tbio

Novelty:  0.00694332

p_int:  0.947272935

p_ni:  0.052726783

p_wrong:  2.81e-7

Data Source:  BioPlex

Pathways (16)

Reactome (15)

WikiPathways (1)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Cilium Assembly	187 targets	R-HSA-5617833
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Gene Ontology Terms (27)

Functions (3)

Components (13)

Processes (11)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
kinesin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein phosphatase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
intraciliary transport particle B binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	1	3	3		85.1
BMI-adjusted waist circumference	EFO_0007789	1	1	1		2.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	3		85.1
BMI-adjusted waist circumference	EFO_0007789	1		2.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
venous thromboembolism

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kinesin associated protein 3	VGNC:6905	457503
Macaque	kinesin associated protein 3		677714
Mouse	kinesin-associated protein 3	MGI:107566	16579
Rat	kinesin-associated protein 3	RGD:1305191	289168
Dog	kinesin associated protein 3	VGNC:42413	100685317

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kinesin associated protein 3
Macaque	kinesin associated protein 3
Mouse	kinesin-associated protein 3
Rat	kinesin-associated protein 3
Dog	kinesin associated protein 3

Publication Statistics

PubMed Score 55.04

PubMed score by year

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PubTator Score 21.25

PubTator score by year

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