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Tbio
KIFAP3
Kinesin-associated protein 3

Protein Summary
Description
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamil ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361580
  • ENSP00000354560
  • ENSG00000075945
  • ENST00000367765
  • ENSP00000356739
  • ENST00000367767
  • ENSP00000356741
  • ENST00000538366
  • ENSP00000444622

Symbol
  • KIF3AP
  • SMAP
  • FLA3
  • KAP3
  • SMAP
  • KAP-1
  • KAP-3
  • Smg-GDS
  • dJ190I16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
virus perturbation
0.85
histone modification site profile
0.79
tissue sample
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (238)
KIF3A
Tbio
Novelty:  0.00555124
p_int:  1
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
KIF3B
Tbio
Novelty:  0.01877656
p_int:  0.999999988
p_ni:  2e-9
p_wrong:  1.1e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
KIF3C
Tbio
Novelty:  0.0512445
p_int:  0.999999952
p_ni:  2e-9
p_wrong:  4.7e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999969567
p_ni:  0.000030417
p_wrong:  1.7e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.99833167
p_ni:  0.001660896
p_wrong:  0.000007435
Score:  0.175
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.997405757
p_ni:  0.002594243
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.993437152
p_ni:  0.006562844
p_wrong:  4e-9
Score:  0.495
Data Source:  BioPlex,STRINGDB
GTF2IRD1
Tbio
Family:  TF
Novelty:  0.01858027
p_int:  0.972914117
p_ni:  0.027075119
p_wrong:  0.000010764
Score:  0.175
Data Source:  BioPlex,STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
p_int:  0.970128886
p_ni:  0.029855788
p_wrong:  0.000015326
Score:  0.182
Data Source:  BioPlex,STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.947272935
p_ni:  0.052726783
p_wrong:  2.81e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cilium Assembly
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cilium Assembly
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
3
85.1
BMI-adjusted waist circumference
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
85.1
BMI-adjusted waist circumference
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin associated protein 3
VGNC:6905
457503
Macaque
kinesin associated protein 3
677714
Mouse
MGI:107566
16579
Rat
RGD:1305191
289168
Dog
kinesin associated protein 3
VGNC:42413
100685317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin associated protein 3
Macaque
kinesin associated protein 3
Mouse
Rat
Dog
kinesin associated protein 3
Publication Statistics
PubMed Score 55.04
PubMed score by year
PubTator Score 21.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title