Tbio KIFAP3 Kinesin-associated protein 3

Protein Summary

Description

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q92845
• B1AKU4
• B1AKU5
• B2RDL1
• B7Z8A3
• F5H591
• Q8NHU7
• Q9H416
• KAP-3

Gene Name

• KIFAP3

Ensembl ID

• ENST00000361580
• ENSP00000354560
• ENSG00000075945
• ENST00000367765
• ENSP00000356739
• ENST00000367767
• ENSP00000356741
• ENST00000538366
• ENSP00000444622

Symbol

• KIF3AP
• SMAP
• FLA3
• KAP3
• SMAP
• KAP-1
• KAP-3
• Smg-GDS
• dJ190I16.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.86
virus perturbation	0.85
histone modification site profile	0.79
tissue sample	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-associated Protein 3

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-associated Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (238)

Explore Interacting Targets

1 – 10 of 238

• See Interactions on String-DB

KIF3A

Tbio

Novelty:  0.00555124

p_int:  1

Score:  0.993

Data Source:  BioPlex,Reactome,STRINGDB

KIF3B

Tbio

Novelty:  0.01877656

p_int:  0.999999988

p_ni:  2e-9

p_wrong:  1.1e-8

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

KIF3C

Tbio

Novelty:  0.0512445

p_int:  0.999999952

p_ni:  2e-9

p_wrong:  4.7e-8

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

RAP1A

Tchem

Family:  Enzyme

Novelty:  0.00375413

p_int:  0.999969567

p_ni:  0.000030417

p_wrong:  1.7e-8

Score:  0.189

Data Source:  BioPlex,STRINGDB

CCNY

Tbio

Novelty:  0.01400663

p_int:  0.99833167

p_ni:  0.001660896

p_wrong:  0.000007435

Score:  0.175

Data Source:  BioPlex,STRINGDB

ERICH5

Tdark

Novelty:  5.57504212

p_int:  0.997405757

p_ni:  0.002594243

Data Source:  BioPlex

SRC

Tclin

Family:  Kinase

Novelty:  0.00008479

p_int:  0.993437152

p_ni:  0.006562844

p_wrong:  4e-9

Score:  0.495

Data Source:  BioPlex,STRINGDB

GTF2IRD1

Tbio

Family:  TF

Novelty:  0.01858027

p_int:  0.972914117

p_ni:  0.027075119

p_wrong:  0.000010764

Score:  0.175

Data Source:  BioPlex,STRINGDB

PAK2

Tchem

Family:  Kinase

Novelty:  0.0149123

p_int:  0.970128886

p_ni:  0.029855788

p_wrong:  0.000015326

Score:  0.182

Data Source:  BioPlex,STRINGDB

VAMP3

Tbio

Novelty:  0.00694332

p_int:  0.947272935

p_ni:  0.052726783

p_wrong:  2.81e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (15)

WikiPathways (1)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Cilium Assembly	187 targets	R-HSA-5617833
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (3)

Components (13)

Processes (11)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
kinesin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein phosphatase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
intraciliary transport particle B binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	1	3	3		85.1
BMI-adjusted waist circumference	EFO_0007789	1	1	1		2.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	3		85.1
BMI-adjusted waist circumference	EFO_0007789	1		2.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
venous thromboembolism

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kinesin associated protein 3	VGNC:6905	457503
Macaque	kinesin associated protein 3		677714
Mouse	kinesin-associated protein 3	MGI:107566	16579
Rat	kinesin-associated protein 3	RGD:1305191	289168
Dog	kinesin associated protein 3	VGNC:42413	100685317

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kinesin associated protein 3
Macaque	kinesin associated protein 3
Mouse	kinesin-associated protein 3
Rat	kinesin-associated protein 3
Dog	kinesin associated protein 3

Publication Statistics

PubMed Score 55.04

PubMed score by year

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PubTator Score 21.25

PubTator score by year

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Related Publications

Text Mined References (32)

GeneRif Annotations (13)

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PMID	Year	Title