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Tbio
TANK
TRAF family member-associated NF-kappa-B activator

Protein Summary
Description
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259075
  • ENSP00000259075
  • ENSG00000136560
  • ENST00000392749
  • ENSP00000376505
  • ENST00000403609
  • ENSP00000385983

Symbol
  • ITRAF
  • TRAF2
  • ITRAF
  • TRAF2
  • I-TRAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
hub protein
0.85
kinase perturbation
0.71
transcription factor
0.71
tissue sample
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.43   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.43   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
4
1
6.3
97.5
lifestyle measurement
1
1
1
74.5
self reported educational attainment
2
1
1
6.5
67.4
smoking behavior
1
1
1
24.3
household income
1
1
1
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.3
97.5
lifestyle measurement
1
74.5
self reported educational attainment
1
6.5
67.4
smoking behavior
1
24.3
household income
1
19.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRAF family member associated NFKB activator
VGNC:2877
459685
Macaque
TRAF family member associated NFKB activator
700942
Mouse
MGI:107676
21353
Rat
RGD:628859
252961
Dog
TRAF family member associated NFKB activator
VGNC:47101
608092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRAF family member associated NFKB activator
Macaque
TRAF family member associated NFKB activator
Mouse
Rat
Dog
TRAF family member associated NFKB activator
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92844-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (236)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MyD88-independent TLR4 cascade
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
MyD88-independent TLR4 cascade
Protein-Protein Interactions (84)
1 – 10 of 84
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.999998343
p_ni: 5.63e-7
p_wrong: 0.000001094
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999997348
p_ni: 0.000002637
p_wrong: 1.6e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999954237
p_ni: 0.000001276
p_wrong: 0.000044487
Data Source: BioPlex
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
p_int: 0.994076015
p_ni: 0.000033816
p_wrong: 0.005890169
Score: 0.966
Data Source: BioPlex,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.996
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.994
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.987
Data Source: Reactome,STRINGDB
IKBKE
Tchem
Family: Kinase
Novelty: 0.01447079
Score: 0.986
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.978
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  95.43

PubMed score by year
PubTator Score  1816.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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