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Tchem
BCL2L2
Bcl-2-like protein 2

Protein Classes
Protein Summary
Description
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250405
  • ENSP00000250405
  • ENSG00000129473
  • ENST00000553781
  • ENSP00000451320
  • ENSG00000258643
  • ENST00000557008
  • ENSP00000452479

Symbol
  • BCLW
  • KIAA0271
  • BCLW
  • BCL-W
  • PPP1R51
  • BCL2-L-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.87
microRNA
0.74
transcription factor perturbation
0.74
cellular component
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.66   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.66   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
venetoclax
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
66.9
monocyte count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
66.9
monocyte count
1
10.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 2
VGNC:12984
100611631
Mouse
MGI:108052
12050
Rat
RGD:620717
60434
Dog
BCL2 like 2
490611
Horse
BCL2 like 2
VGNC:50577
100055644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 2
Mouse
Rat
Dog
BCL2 like 2
Horse
BCL2 like 2
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (79)
1 – 10 of 79
BBC3
Tbio
Novelty: 0.00773944
p_int: 0.999999959
p_ni: 4e-8
Score: 0.833
Data Source: BioPlex,STRINGDB
BAX
Tchem
Novelty: 0.00150653
p_int: 0.999995545
p_ni: 0.000004455
Score: 0.749
Data Source: BioPlex,STRINGDB
BID
Tbio
Novelty: 0.01264688
p_int: 0.998423938
p_ni: 0.001576056
p_wrong: 6e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
p_int: 0.99703184
p_ni: 0.00296815
p_wrong: 1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
p_int: 0.984597891
p_ni: 0.015402109
Score: 0.18
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.902339223
p_ni: 0.000101029
p_wrong: 0.097559748
Data Source: BioPlex
MCL1
Tchem
Novelty: 0.00046181
Score: 0.943
Data Source: STRINGDB
PMAIP1
Tbio
Novelty: 0.00198406
Score: 0.935
Data Source: STRINGDB
HRK
Tbio
Novelty: 0.00304072
Score: 0.932
Data Source: STRINGDB
BIK
Tbio
Novelty: 0.0046334
Score: 0.892
Data Source: STRINGDB
Publication Statistics
PubMed Score  179.66

PubMed score by year
PubTator Score  111.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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