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Tbio
DDX17
Probable ATP-dependent RNA helicase DDX17

Protein Summary
Description
As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:2226686 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000640332
  • ENSP00000491244
  • ENSG00000100201

Symbol
  • P72
  • RH70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
virus perturbation
1
hub protein
0.96
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.29   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.29   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
56.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
56.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 17
VGNC:12843
450181
Macaque
DEAD-box helicase 17
574266
Mouse
MGI:1914290
67040
Dog
DEAD-box helicase 17
VGNC:39846
474508
Horse
DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 17
Macaque
DEAD-box helicase 17
Mouse
Dog
DEAD-box helicase 17
Horse
DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92841-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Protein-Protein Interactions (334)
1 – 10 of 334
FNBP4
Tdark
Novelty: 0.17447776
p_int: 0.999999938
p_ni: 6.2e-8
Score: 0.445
Data Source: BioPlex,STRINGDB
IGHA2
Tbio
p_int: 0.997186984
p_ni: 0.00279409
p_wrong: 0.000018926
Data Source: BioPlex
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00210045
p_int: 0.947780922
p_ni: 0.052219076
p_wrong: 2e-9
Data Source: BioPlex
DDX5
Tbio
Family: Enzyme
Novelty: 0.00637984
p_int: 0.897956328
p_ni: 0.102043672
Score: 0.75
Data Source: BioPlex,STRINGDB
IGHA1
Tbio
p_int: 0.826204645
p_ni: 0.173795353
p_wrong: 3e-9
Data Source: BioPlex
NIF3L1
Tbio
Novelty: 0.15581813
p_int: 0.758657789
p_ni: 0.241342197
p_wrong: 1.4e-8
Score: 0.244
Data Source: BioPlex,STRINGDB
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
p_int: 0.75250211
p_ni: 0.247493462
p_wrong: 0.000004428
Score: 0.256
Data Source: BioPlex,STRINGDB
SRA1
Tbio
Novelty: 0.00495112
Score: 0.989
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.986
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  206.29

PubMed score by year
PubTator Score  119.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer