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Tbio
HAS1
Hyaluronan synthase 1

Protein Summary
Description
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity). Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a varie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222115
  • ENSP00000222115
  • ENSG00000105509

Symbol
  • HAS
  • HAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
virus perturbation
0.68
biological process
0.6
cellular component
0.59
biological term
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.55   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.55   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (49)
1 – 10 of 49
CA1
Tclin
Family:  Enzyme
Novelty:  0.00055482
Score:  0.741
Data Source:  STRINGDB
GPA33
Tbio
Novelty:  0.0081206
Score:  0.669
Data Source:  STRINGDB
LGALS7
Tbio
Novelty:  0.00753996
Score:  0.669
Data Source:  STRINGDB
HMMR
Tchem
Novelty:  0.0039196
Score:  0.666
Data Source:  STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
Score:  0.655
Data Source:  STRINGDB
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
Score:  0.652
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.631
Data Source:  STRINGDB
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
Score:  0.619
Data Source:  STRINGDB
HYAL1
Tbio
Family:  Enzyme
Novelty:  0.00756819
Score:  0.613
Data Source:  STRINGDB
HYAL4
Tbio
Family:  Enzyme
Novelty:  0.10127674
Score:  0.572
Data Source:  STRINGDB
Pathways (6)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan biosynthesis and export
Reactome
Hyaluronan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan biosynthesis and export
Hyaluronan metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
2
2
82.4
eosinophil count
1
2
2
81.8
high density lipoprotein cholesterol measurement
5
3
5
81.5
lymphocyte count
2
2
3
76.7
neutrophil percentage of leukocytes
1
2
2
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
82.4
eosinophil count
2
81.8
high density lipoprotein cholesterol measurement
5
81.5
lymphocyte count
3
76.7
neutrophil percentage of leukocytes
2
71.3
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronan synthase 1
468978
Macaque
hyaluronan synthase 1
719773
Mouse
MGI:106590
15116
Rat
RGD:708528
282821
Dog
hyaluronan synthase 1
VGNC:41599
611700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronan synthase 1
Macaque
hyaluronan synthase 1
Mouse
Rat
Dog
hyaluronan synthase 1
Publication Statistics
PubMed Score 58.55
PubMed score by year
PubTator Score 181.76
PubTator score by year