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Tbio
EDA
Ectodysplasin-A

Protein Summary
Description
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394). May also play a role in cell adhesion (By similarity). Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. Isoform 3: Binds only to the receptor EDA2R. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338901
  • ENSP00000340611
  • ENSG00000158813
  • ENST00000374552
  • ENSP00000363680
  • ENST00000374553
  • ENSP00000363681
  • ENST00000524573
  • ENSP00000432585
  • ENST00000525810
  • ENSP00000434195
  • ENST00000527388
  • ENSP00000434861

Symbol
  • ED1
  • EDA2
  • ED1
  • HED
  • EDA1
  • EDA2
  • HED1
  • ODT1
  • XHED
  • ECTD1
  • XLHED
  • ED1-A1
  • ED1-A2
  • EDA-A1
  • EDA-A2
  • TNLG7C
  • STHAGX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
biological process
0.75
cellular component
0.73
phenotype
0.66
biological term
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.96   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.96   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.999986148
p_ni:  0.000013851
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
p_int:  0.999980969
p_ni:  0.000019022
p_wrong:  9e-9
Data Source:  BioPlex
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.999977156
p_ni:  0.000017498
p_wrong:  0.000005346
Data Source:  BioPlex
AP3B2
Tbio
Novelty:  0.11897342
p_int:  0.999972391
p_ni:  0.000027608
p_wrong:  1e-9
Score:  0.51
Data Source:  BioPlex,STRINGDB
AP3B1
Tbio
Novelty:  0.03117931
p_int:  0.999951852
p_ni:  0.000048148
Data Source:  BioPlex
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999913375
p_ni:  0.000077474
p_wrong:  0.000009151
Data Source:  BioPlex
AP3M2
Tbio
Novelty:  0.18164255
p_int:  0.999697945
p_ni:  0.000301916
p_wrong:  1.39e-7
Score:  0.307
Data Source:  BioPlex,STRINGDB
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.999463238
p_ni:  0.000536762
Score:  0.328
Data Source:  BioPlex,STRINGDB
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.99892552
p_ni:  0.001074476
p_wrong:  4e-9
Data Source:  BioPlex
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.998605393
p_ni:  0.001394604
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (66)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
1
1
81.5
balding measurement
1
1
1
64.9
chronotype measurement
1
1
1
31.3
tooth eruption
1
1
1
24.2
odontogenesis
1
1
1
17.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
81.5
balding measurement
1
64.9
chronotype measurement
1
31.3
tooth eruption
1
24.2
odontogenesis
1
17.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectodysplasin A
101058344
Macaque
ectodysplasin-A
694110
Mouse
MGI:1195272
13607
Rat
RGD:1563178
302424
Dog
ectodysplasin A
VGNC:54136
491935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectodysplasin A
Macaque
ectodysplasin-A
Mouse
Rat
Dog
ectodysplasin A
Publication Statistics
PubMed Score 281.96
PubMed score by year
PubTator Score 1177.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text