You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
INPP5D
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Protein Summary
Description
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359570
  • ENSP00000352575
  • ENSG00000168918
  • ENST00000445964
  • ENSP00000405338
  • ENST00000629761
  • ENSP00000486669
  • ENSG00000281614
  • ENST00000630854
  • ENSP00000487191

Symbol
  • SHIP
  • SHIP1
  • SHIP
  • SHIP1
  • SHIP-1
  • hp51CN
  • SIP-145
  • p150Ship
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.8
tissue sample
0.72
hub protein
0.71
transcription factor
0.7
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.68   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 515   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.68   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
89.4
eosinophil count
3
3
4
89.4
3
2
0
3.5
81.8
3
2
0
3.5
81.8
family history of Alzheimer’s disease
2
2
0
5.8
81
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
89.4
eosinophil count
4
89.4
0
3.5
81.8
0
3.5
81.8
family history of Alzheimer’s disease
0
5.8
81
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase D
VGNC:50731
470683
Macaque
inositol polyphosphate-5-phosphatase D
717832
Mouse
MGI:107357
16331
Rat
RGD:2914
54259
Dog
inositol polyphosphate-5-phosphatase D
VGNC:42032
100688270
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase D
Macaque
inositol polyphosphate-5-phosphatase D
Mouse
Rat
Dog
inositol polyphosphate-5-phosphatase D
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92835-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (53)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Downstream TCR signaling
Hemostasis
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (209)
1 – 10 of 209
SHC1
Tchem
Novelty: 0.00083615
Score: 0.976
Data Source: Reactome,STRINGDB
FCGR2B
Tbio
Novelty: 0.00098166
Score: 0.974
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.964
Data Source: STRINGDB
BTK
Tclin
Family: Kinase
Novelty: 0.00050747
Score: 0.964
Data Source: STRINGDB
DOK1
Tbio
Novelty: 0.01976327
Score: 0.957
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.956
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.956
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.955
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.955
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  142.68

PubMed score by year
PubTator Score  1910.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: