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Tbio
RPGR
X-linked retinitis pigmentosa GTPase regulator

Protein Classes
Protein Summary
Description
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia. This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have bee ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318842
  • ENSP00000322219
  • ENSG00000156313
  • ENST00000339363
  • ENSP00000343671
  • ENST00000378505
  • ENSP00000367766
  • ENST00000474584
  • ENSP00000418926
  • ENST00000482855
  • ENSP00000419276
  • ENST00000642395
  • ENSP00000493468
  • ENST00000644337
  • ENSP00000494557
  • ENST00000645032
  • ENSP00000495537

Symbol
  • RP3
  • XLRP3
  • CRD
  • RP3
  • COD1
  • PCDX
  • RP15
  • XLRP3
  • orf15
  • CORDX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
histone modification site profile
0.76
biological term
0.7
small molecule perturbation
0.64
phenotype
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.24   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.24   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
retinitis pigmentosa GTPase regulator
714316
Mouse
MGI:1344037
19893
Horse
retinitis pigmentosa GTPase regulator
100055608
Opossum
retinitis pigmentosa GTPase regulator
107648898
Zebrafish
ZDB-GENE-081015-2
557752
Species
Name
OMA
EggNOG
Inparanoid
Macaque
retinitis pigmentosa GTPase regulator
Mouse
Horse
retinitis pigmentosa GTPase regulator
Opossum
retinitis pigmentosa GTPase regulator
Zebrafish
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92834-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (199)
1 – 10 of 199
RPGRIP1L
Tbio
Novelty: 0.00819421
p_int: 1
Score: 0.969
Data Source: BioPlex,STRINGDB
NPHP4
Tbio
Novelty: 0.02873746
p_int: 0.999999949
p_ni: 4.3e-8
p_wrong: 8e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
ORC2
Tbio
Novelty: 0.11963517
p_int: 0.999998973
p_ni: 9.15e-7
p_wrong: 1.12e-7
Score: 0.296
Data Source: BioPlex,STRINGDB
ORC3
Tbio
Novelty: 0.03409802
p_int: 0.999998934
p_ni: 9.94e-7
p_wrong: 7.2e-8
Score: 0.245
Data Source: BioPlex,STRINGDB
ATP1A4
Tclin
Family: Transporter
Novelty: 0.01011201
p_int: 0.999986817
p_ni: 0.00001316
p_wrong: 2.4e-8
Score: 0.296
Data Source: BioPlex,STRINGDB
NR2F2
Tbio
Family: NR
Novelty: 0.00450561
p_int: 0.999969496
p_ni: 0.000030503
Data Source: BioPlex
NPHP1
Tbio
Novelty: 0.01113034
p_int: 0.99992892
p_ni: 0.000056743
p_wrong: 0.000014336
Score: 0.948
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999782267
p_ni: 0.000217733
Score: 0.182
Data Source: BioPlex,STRINGDB
FAM126A
Tbio
Novelty: 0.0250547
p_int: 0.998946778
p_ni: 0.001053008
p_wrong: 2.14e-7
Score: 0.564
Data Source: BioPlex,STRINGDB
SPSB3
Tdark
Novelty: 0.07215887
p_int: 0.998182666
p_ni: 0.001815977
p_wrong: 0.000001357
Score: 0.198
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  394.24

PubMed score by year
PubTator Score  264.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer