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Tbio
JARID2
Protein Jumonji

Protein Summary
Description
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341776
  • ENSP00000341280
  • ENSG00000008083
  • ENST00000397311
  • ENSP00000380478

Symbol
  • JMJ
  • JMJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.94
transcription factor perturbation
0.88
transcription factor
0.85
biological process
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.33   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.33   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (162)
1 – 10 of 162
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  6e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
p_int:  0.99999999
p_ni:  5e-9
p_wrong:  4e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
AEBP2
Tbio
Novelty:  0.05974483
p_int:  0.999999947
p_ni:  5e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.995
Data Source:  Reactome,STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.995
Data Source:  Reactome,STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
Score:  0.98
Data Source:  Reactome,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.978
Data Source:  Reactome,STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
Score:  0.962
Data Source:  STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.957
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.957
Data Source:  STRINGDB
Pathways (7)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
PRC2 methylates histones and DNA
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
PRC2 methylates histones and DNA
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
7
81.6
lymphocyte count
2
2
2
78.7
2
1
2
46.1
BMI-adjusted hip circumference
1
1
1
36.9
grip strength measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7
81.6
lymphocyte count
2
78.7
2
46.1
BMI-adjusted hip circumference
1
36.9
grip strength measurement
1
36.9
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jumonji and AT-rich interaction domain containing 2
VGNC:3257
462450
Macaque
jumonji and AT-rich interaction domain containing 2
702291
Mouse
MGI:104813
16468
Rat
RGD:1591663
681740
Dog
jumonji and AT-rich interaction domain containing 2
VGNC:42181
478729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jumonji and AT-rich interaction domain containing 2
Macaque
jumonji and AT-rich interaction domain containing 2
Mouse
Rat
Dog
jumonji and AT-rich interaction domain containing 2
Publication Statistics
PubMed Score 129.33
PubMed score by year
PubTator Score 54.72
PubTator score by year