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Tchem
KAT2B
Histone acetyltransferase KAT2B

Protein Summary
Description
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263754
  • ENSP00000263754
  • ENSG00000114166

Symbol
  • PCAF
  • CAF
  • PCAF
  • P/CAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
biological process
0.98
hub protein
0.98
molecular function
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.9   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.9   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (42)
1 – 10 of 42
epigallocatechin gallate
Rendered image for epigallocatechin gallate
plumbagin
Rendered image for plumbagin
CHEMBL4069412
Rendered image for CHEMBL4069412
CHEMBL4574669
Rendered image for CHEMBL4574669
anacardic acid
Rendered image for anacardic acid
garcinol
Rendered image for garcinol
Lys-CoA
no chemical structure image available
compound 1 [PMID: 15724976]
Rendered image for compound 1 [PMID: 15724976]
CHEMBL4543497
Rendered image for CHEMBL4543497
CHEMBL4103402
Rendered image for CHEMBL4103402
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
2
3
94.2
mean reticulocyte volume
1
1
1
86
mean corpuscular hemoglobin concentration
1
1
1
82.3
heel bone mineral density
2
2
2
78.7
reticulocyte measurement
2
2
2
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
94.2
mean reticulocyte volume
1
86
mean corpuscular hemoglobin concentration
1
82.3
heel bone mineral density
2
78.7
reticulocyte measurement
2
71.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 2B
VGNC:7977
460219
Macaque
lysine acetyltransferase 2B
698283
Mouse
MGI:1343094
18519
Dog
lysine acetyltransferase 2B
VGNC:42210
477052
Horse
lysine acetyltransferase 2B
VGNC:19242
100061976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 2B
Macaque
lysine acetyltransferase 2B
Mouse
Dog
lysine acetyltransferase 2B
Horse
lysine acetyltransferase 2B
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92831-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (71)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cardiac conduction
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Cardiac conduction
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (499)
1 – 10 of 499
DR1
Tbio
Novelty:  0.00138571
p_int:  0.999999945
p_ni:  5.5e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.999999937
p_ni:  6.2e-8
p_wrong:  1e-9
Score:  0.495
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999999889
p_ni:  6.4e-8
p_wrong:  4.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999999832
p_ni:  1.68e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999999374
p_ni:  6.26e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999238
p_ni:  7.61e-7
p_wrong:  1e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999995361
p_ni:  0.000004639
Score:  0.997
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999991007
p_ni:  0.000008821
p_wrong:  1.73e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.99999077
p_ni:  0.00000923
Score:  0.573
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  499.90

PubMed score by year
PubTator Score  515.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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