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Tbio
HOXB13
Homeobox protein Hox-B13

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290295
  • ENSP00000290295
  • ENSG00000159184

Symbol
  • HPC9
  • PSGD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
PubMedID
0.72
biological process
0.67
biological term
0.65
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.92   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.92   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
2
1
0
4.2
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
4.2
93.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B13
VGNC:12280
468433
Mouse
MGI:107730
15408
Rat
RGD:1309113
303480
Dog
homeobox B13
VGNC:41750
491060
Horse
homeobox B13
VGNC:18843
100055745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B13
Mouse
Rat
Dog
homeobox B13
Horse
homeobox B13
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (35)
1 – 10 of 35
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.979
Data Source: STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
Score: 0.964
Data Source: STRINGDB
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
Score: 0.96
Data Source: STRINGDB
PRAC1
Tbio
Novelty: 0.03902014
Score: 0.932
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.911
Data Source: STRINGDB
PRAC2
Tdark
Novelty: 0.40769089
Score: 0.908
Data Source: STRINGDB
PRRX2
Tbio
Family: TF
Novelty: 0.08230504
Score: 0.811
Data Source: STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
Score: 0.749
Data Source: STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
Score: 0.749
Data Source: STRINGDB
TEAD3
Tbio
Family: TF
Novelty: 0.04014337
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  184.92

PubMed score by year
PubTator Score  124.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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