Tchem PCSK5 Proprotein convertase subtilisin/kexin type 5

Protein Summary

Description

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q92824
• F5H2G7
• Q13527
• Q96EP4

Gene Name

• PCSK5

Ensembl ID

• ENST00000376752
• ENSP00000365943
• ENSG00000099139
• ENST00000545128
• ENSP00000446280

Symbol

• PC5
• PC6
• PC5
• PC6
• PC6A
• SPC6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
phenotype	0.84
transcription factor perturbation	0.84
virus perturbation	0.83
cellular component	0.76

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Proprotein Convertase Subtilisin/kexin Type 5

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Proprotein Convertase Subtilisin/kexin Type 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2011.63   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2011.63   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0