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Tchem
PCSK5
Proprotein convertase subtilisin/kexin type 5

Protein Summary
Description
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376752
  • ENSP00000365943
  • ENSG00000099139
  • ENST00000545128
  • ENSP00000446280

Symbol
  • PC5
  • PC6
  • PC5
  • PC6
  • PC6A
  • SPC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
phenotype
0.84
transcription factor perturbation
0.84
virus perturbation
0.83
cellular component
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1438.11   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1438.11   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (77)
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.990909277
p_ni:  0.00399577
p_wrong:  0.005094952
Data Source:  BioPlex
LYPD1
Tbio
Novelty:  0.10740408
p_int:  0.989888153
p_ni:  0.010111835
p_wrong:  1.2e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.983502869
p_ni:  0.014759757
p_wrong:  0.001737374
Data Source:  BioPlex
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.976054432
p_ni:  0.019189343
p_wrong:  0.004756225
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.967035158
p_ni:  0.028988127
p_wrong:  0.003976715
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.962618184
p_ni:  0.035181369
p_wrong:  0.002200447
Score:  0.313
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.955005594
p_ni:  0.034682575
p_wrong:  0.010311831
Data Source:  BioPlex
CD160
Tbio
Novelty:  0.01511748
p_int:  0.93434762
p_ni:  0.061222648
p_wrong:  0.004429733
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.9326959
p_ni:  0.052611547
p_wrong:  0.014692553
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.922177924
p_ni:  0.064077984
p_wrong:  0.013744092
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Expression and Processing of Neurotrophins
Reactome
NGF processing
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Expression and Processing of Neurotrophins
NGF processing
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
8
8
91.9
body height
3
3
4
90.5
body fat distribution
2
1
4
80.3
anthropometric measurement
1
1
0
1.5
66
BMI-adjusted hip circumference
2
2
2
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
8
91.9
body height
4
90.5
body fat distribution
4
80.3
anthropometric measurement
0
1.5
66
BMI-adjusted hip circumference
2
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 5
VGNC:9185
464533
Macaque
proprotein convertase subtilisin/kexin type 5
704428
Mouse
MGI:97515
18552
Rat
RGD:620326
116548
Dog
proprotein convertase subtilisin/kexin type 5
VGNC:44324
484160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 5
Macaque
proprotein convertase subtilisin/kexin type 5
Mouse
Rat
Dog
proprotein convertase subtilisin/kexin type 5
Publication Statistics
PubMed Score 1438.11
PubMed score by year
PubTator Score 433.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title