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Tbio
NRCAM
Neuronal cell adhesion molecule

Protein Summary
Description
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351718
  • ENSP00000325269
  • ENSG00000091129
  • ENST00000379024
  • ENSP00000368310
  • ENST00000379028
  • ENSP00000368314
  • ENST00000425651
  • ENSP00000401244

Symbol
  • KIAA0343
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.92
transcription factor perturbation
0.88
PubMedID
0.86
small molecule perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.75   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.75   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
ANK3
Tbio
Novelty:  0.00429246
Score:  0.987
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.984
Data Source:  Reactome,STRINGDB
CNTN2
Tbio
Novelty:  0.00213251
Score:  0.959
Data Source:  Reactome,STRINGDB
KCNQ2
Tclin
Family:  IC
Novelty:  0.00209684
Score:  0.958
Data Source:  Reactome,STRINGDB
SCN8A
Tclin
Family:  IC
Novelty:  0.00203805
Score:  0.957
Data Source:  STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
Score:  0.957
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.952
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.951
Data Source:  Reactome,STRINGDB
GLDN
Tbio
Novelty:  0.01859604
Score:  0.95
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.948
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Reactome
Neurofascin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Neurofascin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption
1
4.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal cell adhesion molecule
VGNC:4449
463658
Macaque
neuronal cell adhesion molecule
574228
Mouse
MGI:104750
319504
Rat
RGD:3209
497815
Dog
neuronal cell adhesion molecule
VGNC:43963
475881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal cell adhesion molecule
Macaque
neuronal cell adhesion molecule
Mouse
Rat
Dog
neuronal cell adhesion molecule
Publication Statistics
PubMed Score 210.75
PubMed score by year
PubTator Score 90.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title