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Tchem
GGH
Gamma-glutamyl hydrolase

Protein Summary
Description
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260118
  • ENSP00000260118
  • ENSG00000137563

Symbol
  • GH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.86
kinase perturbation
0.81
cell line
0.72
cellular component
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.8   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.8   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyl hydrolase
VGNC:6676
464204
Mouse
MGI:1329035
14590
Rat
RGD:2682
25455
Dog
gamma-glutamyl hydrolase
VGNC:41198
100856436
Horse
gamma-glutamyl hydrolase
VGNC:18325
100052567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyl hydrolase
Mouse
Rat
Dog
gamma-glutamyl hydrolase
Horse
gamma-glutamyl hydrolase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92820-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (263)
1 – 10 of 263
UGDH
Tbio
Family: Enzyme
Novelty: 0.00284931
p_int: 0.997556479
p_ni: 0.002443521
Score: 0.674
Data Source: BioPlex,STRINGDB
TGOLN2
Tbio
Novelty: 0.005107
p_int: 0.965242361
p_ni: 0.034757639
Data Source: BioPlex
ITGAV
Tchem
Novelty: 0.00148589
p_int: 0.916876514
p_ni: 0.083123486
Score: 0.173
Data Source: BioPlex,STRINGDB
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.868372767
p_ni: 0.131627233
Score: 0.183
Data Source: BioPlex,STRINGDB
MICA
Tbio
Novelty: 0.03965901
p_int: 0.868231413
p_ni: 0.131765635
p_wrong: 0.000002952
Data Source: BioPlex
TXNDC16
Tdark
Novelty: 0.25365147
p_int: 0.836070585
p_ni: 0.163929161
p_wrong: 2.54e-7
Score: 0.567
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.811579182
p_ni: 0.188420818
Score: 0.417
Data Source: BioPlex,STRINGDB
CERCAM
Tdark
Family: Enzyme
Novelty: 0.33392502
p_int: 0.780194288
p_ni: 0.219805623
p_wrong: 8.9e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
FPGS
Tchem
Family: Enzyme
Novelty: 0.0108601
Score: 0.986
Data Source: STRINGDB
DHFR
Tclin
Family: Enzyme
Novelty: 0.00074557
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.80

PubMed score by year
PubTator Score  115.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer