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Tbio
HAS2
Hyaluronan synthase 2

Protein Summary
Description
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extrac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303924
  • ENSP00000306991
  • ENSG00000170961
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.97
pathway
0.92
biological process
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.76   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.76   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
42.3
Pathways (6)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan biosynthesis and export
Reactome
Hyaluronan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan biosynthesis and export
Hyaluronan metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (28)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Protein-Protein Interactions (77)
1 – 10 of 77
HYAL1
Tbio
Family: Enzyme
Novelty: 0.00756819
Score: 0.817
Data Source: STRINGDB
HYAL2
Tbio
Family: Enzyme
Novelty: 0.00740331
Score: 0.815
Data Source: STRINGDB
HMMR
Tbio
Novelty: 0.0039196
Score: 0.804
Data Source: STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.8
Data Source: STRINGDB
SPAM1
Tbio
Family: Enzyme
Novelty: 0.0041597
Score: 0.772
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.747
Data Source: STRINGDB
TNFAIP6
Tbio
Novelty: 0.0046811
Score: 0.725
Data Source: STRINGDB
AREG
Tbio
Novelty: 0.0017631
Score: 0.674
Data Source: STRINGDB
HABP2
Tbio
Family: Enzyme
Novelty: 0.00332789
Score: 0.665
Data Source: STRINGDB
PTX3
Tbio
Novelty: 0.00153752
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  408.76

PubMed score by year
PubTator Score  403.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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