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Tbio
SYMPK
Symplekin

Protein Summary
Description
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245934
  • ENSP00000245934
  • ENSG00000125755

Symbol
  • SPK
  • SPK
  • SYM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
histone modification site profile
0.79
disease perturbation
0.74
transcription factor binding site profile
0.72
protein complex
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
56.2
eosinophil percentage of leukocytes
1
1
1
43.3
colonic neoplasm
1
1
0
1.6
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
56.2
eosinophil percentage of leukocytes
1
43.3
colonic neoplasm
0
1.6
38.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
symplekin
VGNC:2240
456142
Macaque
symplekin
722436
Mouse
MGI:1915438
68188
Rat
RGD:1306735
292683
Dog
symplekin
VGNC:47022
476431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
symplekin
Macaque
symplekin
Mouse
Rat
Dog
symplekin
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92797-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (315)
1 – 10 of 315
CPEB1
Tbio
Novelty: 0.00444378
p_int: 0.999993197
p_ni: 0.000006794
p_wrong: 9e-9
Score: 0.947
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.999965065
p_ni: 0.000034933
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CSTF2T
Tbio
Novelty: 0.11811814
p_int: 0.999949385
p_ni: 0.000050614
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.999938519
p_ni: 0.000061475
p_wrong: 6e-9
Data Source: BioPlex
CPSF2
Tbio
Novelty: 0.0510853
p_int: 0.999755555
p_ni: 0.000244293
p_wrong: 1.52e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
BSG
Tbio
Novelty: 0.0010285
p_int: 0.999160089
p_ni: 0.000839911
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.998669305
p_ni: 0.001330691
p_wrong: 4e-9
Data Source: BioPlex
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.997766731
p_ni: 0.002233269
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.995674344
p_ni: 0.004325656
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.994731707
p_ni: 0.005268064
p_wrong: 2.29e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  51.44

PubMed score by year
PubTator Score  35.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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