DLG3
Disks large homolog 3
Protein Summary
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
- ENST00000374355
- ENSP00000363475
- ENSG00000082458
- ENST00000374360
- ENSP00000363480
- ENST00000542398
- ENSP00000441393
- KIAA1232
- MRX
- XLMR
- MRX90
- NEDLG
- SAP102
- PPP1R82
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
protein domain | 0.99 | ||
disease perturbation | 0.9 | ||
cellular component | 0.82 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.78 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 303 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.78 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 303 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0