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Tbio
DLG3
Disks large homolog 3

Protein Summary
Description
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374355
  • ENSP00000363475
  • ENSG00000082458
  • ENST00000374360
  • ENSP00000363480
  • ENST00000542398
  • ENSP00000441393

Symbol
  • KIAA1232
  • MRX
  • XLMR
  • MRX90
  • NEDLG
  • SAP102
  • PPP1R82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.99
disease perturbation
0.9
cellular component
0.82
molecular function
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.48   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.48   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
48.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
48.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 3
VGNC:12291
100609853
Macaque
discs large MAGUK scaffold protein 3
697179
Mouse
MGI:1888986
53310
Rat
RGD:68423
58948
Opossum
discs large MAGUK scaffold protein 3
100011645
Species
Name
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 3
Macaque
discs large MAGUK scaffold protein 3
Mouse
Rat
Opossum
discs large MAGUK scaffold protein 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92796-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of NMDA receptors and postsynaptic events
Activation of kainate receptors upon glutamate binding
Assembly and cell surface presentation of NMDA receptors
Axon guidance
Gene Ontology Terms (35)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (205)
1 – 10 of 205
ARHGAP17
Tbio
Family: Enzyme
Novelty: 0.06611987
p_int: 0.999999987
p_ni: 1.3e-8
Data Source: BioPlex
RALGAPA2
Tdark
Family: Enzyme
Novelty: 0.12467725
p_int: 0.999999898
p_ni: 1.02e-7
Data Source: BioPlex
ARHGEF26
Tbio
Novelty: 0.09349583
p_int: 0.999999866
p_ni: 1.34e-7
Data Source: BioPlex
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
p_int: 0.999999742
p_ni: 2.58e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
p_int: 0.99999847
p_ni: 4.6e-8
p_wrong: 0.000001484
Score: 0.929
Data Source: BioPlex,STRINGDB
RALGAPB
Tbio
Family: Enzyme
Novelty: 0.31941838
p_int: 0.999997992
p_ni: 0.000002008
Data Source: BioPlex
CNPY2
Tbio
Novelty: 0.090889
p_int: 0.99999565
p_ni: 0.000004348
p_wrong: 2e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
NEDD4L
Tbio
Family: Enzyme
Novelty: 0.00250567
p_int: 0.999982044
p_ni: 0.000017956
Score: 0.329
Data Source: BioPlex,STRINGDB
RHBDL1
Tdark
Family: Enzyme
Novelty: 0.63616927
p_int: 0.999960618
p_ni: 0.000039374
p_wrong: 8e-9
Score: 0.489
Data Source: BioPlex,STRINGDB
NBEA
Tbio
Novelty: 0.02583687
p_int: 0.999569824
p_ni: 0.000430175
Score: 0.669
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  79.48

PubMed score by year
PubTator Score  164.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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