Tchem KAT6A Histone acetyltransferase KAT6A

Protein Summary

Description

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q92794
• Q76L81

Gene Name

• KAT6A

Ensembl ID

• ENST00000265713
• ENSP00000265713
• ENSG00000083168
• ENST00000396930
• ENSP00000380136

Symbol

• MOZ
• MYST3
• RUNXBP2
• ZNF220
• MOZ
• MRD32
• MYST3
• MYST-3
• ZNF220
• RUNXBP2
• ZC2HC6A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor binding site profile	0.95
biological process	0.92
molecular function	0.9
microRNA	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Histone Acetyltransferase Kat6a

Protein / Transcription Factor / Zinc Finger Transcription Factor / Histone Acetyltransferase Kat6a

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Acetyltransferase Kat6a

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Histone Acetyltransferase Kat6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.06   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.06   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0