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Tbio
KAT6A
Histone acetyltransferase KAT6A

Protein Summary
Description
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265713
  • ENSP00000265713
  • ENSG00000083168
  • ENST00000396930
  • ENSP00000380136

Symbol
  • MOZ
  • MYST3
  • RUNXBP2
  • ZNF220
  • MOZ
  • MRD32
  • MYST3
  • MYST-3
  • ZNF220
  • RUNXBP2
  • ZC2HC6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.95
biological process
0.92
molecular function
0.9
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.97   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.97   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (108)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (174)
1 – 10 of 174
MEAF6
Tbio
Novelty: 0.2575873
p_int: 0.999993516
p_ni: 0.000006461
p_wrong: 2.2e-8
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.999977568
p_ni: 0.00002162
p_wrong: 8.12e-7
Data Source: BioPlex
BRPF1
Tchem
Family: Epigenetic
Novelty: 0.00091567
Score: 0.995
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.994
Data Source: STRINGDB
ING5
Tbio
Family: Epigenetic
Novelty: 0.03831116
Score: 0.99
Data Source: Reactome,STRINGDB
BRD1
Tchem
Family: Epigenetic
Novelty: 0.00072503
Score: 0.989
Data Source: STRINGDB
BRPF3
Tchem
Family: Epigenetic
Novelty: 0.22263451
Score: 0.988
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00643607
Score: 0.986
Data Source: Reactome,STRINGDB
H3F3C
Tbio
Novelty: 0.07556919
Score: 0.973
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.973
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  119.97

PubMed score by year
PubTator Score  72.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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