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Tchem
CREBBP
CREB-binding protein

Protein Summary
Description
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic develo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262367
  • ENSP00000262367
  • ENSG00000005339
  • ENST00000382070
  • ENSP00000371502

Symbol
  • CBP
  • CBP
  • RSTS
  • KAT3A
  • MKHK1
  • RSTS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
pathway
1
viral protein
1
virus
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.5   (req: < 5)
Gene RIFs: 242   (req: <= 3)
Antibodies: 595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.5   (req: >= 5)
Gene RIFs: 242   (req: > 3)
Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (182)
1 – 10 of 182
CHEMBL4173488
Rendered image for CHEMBL4173488
CHEMBL4436408
Rendered image for CHEMBL4436408
US9458145, 1020-18
Rendered image for US9458145, 1020-18
CHEMBL4171228
Rendered image for CHEMBL4171228
CHEMBL4063051
Rendered image for CHEMBL4063051
CHEMBL3786012
Rendered image for CHEMBL3786012
CHEMBL3108800
Rendered image for CHEMBL3108800
CHEMBL3581661
Rendered image for CHEMBL3581661
US8975417, 170
Rendered image for US8975417, 170
US8975417, 94
Rendered image for US8975417, 94
Protein-Protein Interactions (759)
1 – 10 of 759
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.999999991
p_ni:  9e-9
Score:  0.951
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999071
p_ni:  9.05e-7
p_wrong:  2.4e-8
Score:  0.738
Data Source:  BioPlex,STRINGDB
C3orf62
Tdark
Novelty:  1.85670012
p_int:  0.999997224
p_ni:  0.000002759
p_wrong:  1.7e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999994989
p_ni:  0.000005002
p_wrong:  9e-9
Score:  0.766
Data Source:  BioPlex,STRINGDB
CTGF
Tbio
Novelty:  0.0004346
p_int:  0.999958325
p_ni:  0.000041675
Score:  0.351
Data Source:  BioPlex,STRINGDB
TXNDC11
Tbio
Novelty:  0.07135045
p_int:  0.995742706
p_ni:  0.004255897
p_wrong:  0.000001398
Score:  0.64
Data Source:  BioPlex,STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.991141932
p_ni:  0.008857955
p_wrong:  1.14e-7
Score:  0.848
Data Source:  BioPlex,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.981223485
p_ni:  0.018749548
p_wrong:  0.000026967
Score:  0.839
Data Source:  BioPlex,STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
p_int:  0.980710644
p_ni:  0.019288073
p_wrong:  0.000001283
Score:  0.691
Data Source:  BioPlex,STRINGDB
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.765868302
p_ni:  0.233687647
p_wrong:  0.000444051
Data Source:  BioPlex
Pathways (187)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 82
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Attenuation phase
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of gene expression by SREBF (SREBP)
Activation of the TFAP2 (AP-2) family of transcription factors
Attenuation phase
Gene Ontology Terms (51)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
91.8
body mass index
8
5
11
89.2
neutrophil count
3
2
4
88.7
body height
2
2
2
87.6
leukocyte count
2
2
3
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
91.8
body mass index
11
89.2
neutrophil count
4
88.7
body height
2
87.6
leukocyte count
3
86.3
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CREB binding protein
VGNC:5745
467891
Macaque
CREB binding protein
704331
Mouse
MGI:1098280
12914
Rat
RGD:2401
54244
Dog
CREB binding protein
VGNC:39601
479866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CREB binding protein
Macaque
CREB binding protein
Mouse
Rat
Dog
CREB binding protein
Publication Statistics
PubMed Score 622.50
PubMed score by year
PubTator Score 1717.41
PubTator score by year