Protein Summary
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic develo ...more
- ENST00000262367
- ENSP00000262367
- ENSG00000005339
- ENST00000382070
- ENSP00000371502
- CBP
- CBP
- RSTS
- KAT3A
- MKHK1
- RSTS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
molecular function | 1 | ||
pathway | 1 | ||
viral protein | 1 | ||
virus | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 622.5 (req: < 5)
Gene RIFs: 242 (req: <= 3)
Antibodies: 595 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 622.5 (req: >= 5)
Gene RIFs: 242 (req: > 3)
Antibodies: 595 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 182
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (182)
Protein-Protein Interactions (759)
CITED1
Novelty: 0.01956689
p_int: 0.999999991
p_ni: 9e-9
Score: 0.951
Data Source: BioPlex,STRINGDB
CCNA2
Novelty: 0.00049887
p_int: 0.999999071
p_ni: 9.05e-7
p_wrong: 2.4e-8
Score: 0.738
Data Source: BioPlex,STRINGDB
C3orf62
Novelty: 1.85670012
p_int: 0.999997224
p_ni: 0.000002759
p_wrong: 1.7e-8
Score: 0.332
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.999994989
p_ni: 0.000005002
p_wrong: 9e-9
Score: 0.766
Data Source: BioPlex,STRINGDB
CTGF
Novelty: 0.0004346
p_int: 0.999958325
p_ni: 0.000041675
Score: 0.351
Data Source: BioPlex,STRINGDB
TXNDC11
Novelty: 0.07135045
p_int: 0.995742706
p_ni: 0.004255897
p_wrong: 0.000001398
Score: 0.64
Data Source: BioPlex,STRINGDB
STAT2
Family: TF
Novelty: 0.00241454
p_int: 0.991141932
p_ni: 0.008857955
p_wrong: 1.14e-7
Score: 0.848
Data Source: BioPlex,STRINGDB
CCND3
Novelty: 0.00223085
p_int: 0.981223485
p_ni: 0.018749548
p_wrong: 0.000026967
Score: 0.839
Data Source: BioPlex,STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00033009
p_int: 0.980710644
p_ni: 0.019288073
p_wrong: 0.000001283
Score: 0.691
Data Source: BioPlex,STRINGDB
CHURC1
Novelty: 0.05885372
p_int: 0.765868302
p_ni: 0.233687647
p_wrong: 0.000444051
Data Source: BioPlex
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
GSK3B
Pathways (187)
Reactome (82)
KEGG (25)
PathwayCommons (61)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Activation of the TFAP2 (AP-2) family of transcription factors | ||||
Reactome | Attenuation phase | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Activation of gene expression by SREBF (SREBP) | ||||
Activation of the TFAP2 (AP-2) family of transcription factors | ||||
Attenuation phase | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (15)
Components (6)
Processes (30)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 4 | 5 | 91.8 | |||||
body mass index | 8 | 5 | 11 | 89.2 | |||||
neutrophil count | 3 | 2 | 4 | 88.7 | |||||
body height | 2 | 2 | 2 | 87.6 | |||||
leukocyte count | 2 | 2 | 3 | 86.3 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 5 | 91.8 | |||||
body mass index | 11 | 89.2 | |||||
neutrophil count | 4 | 88.7 | |||||
body height | 2 | 87.6 | |||||
leukocyte count | 3 | 86.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CREB binding protein | VGNC:5745 | 467891 | |||||
Macaque | CREB binding protein | 704331 | ||||||
Mouse | MGI:1098280 | 12914 | ||||||
Rat | RGD:2401 | 54244 | ||||||
Dog | CREB binding protein | VGNC:39601 | 479866 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CREB binding protein | |||||
Macaque | CREB binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | CREB binding protein | |||||
Publication Statistics
PubMed Score 622.50
PubMed score by year
PubTator Score 1717.41
PubTator score by year
Related Publications
Text Mined References (518)
GeneRif Annotations (242)
Items per page:
0 of 0
PMID | Year | Title |
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