Tbio DPF2 Zinc finger protein ubi-d4

Protein Summary

Description

Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92785
• A8K7C9
• B4DT58

Gene Name

• DPF2

Ensembl ID

• ENST00000415073
• ENSP00000399714
• ENSG00000133884
• ENST00000528416
• ENSP00000436901

Symbol

• BAF45D
• REQ
• UBID4
• REQ
• CSS7
• UBID4
• ubi-d4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
protein domain	0.97
interacting protein	0.94
drug perturbation	0.87
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Zinc Finger Protein Ubi-d4

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Ubi-d4

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Zinc Finger Protein Ubi-d4

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Zinc Finger Protein Ubi-d4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.82   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 297   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.82   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0