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Tbio
STAM
Signal transducing adapter molecule 1

Protein Summary
Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377524
  • ENSP00000366746
  • ENSG00000136738

Symbol
  • STAM1
  • STAM1
  • STAM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.96
interacting protein
0.92
histone modification site profile
0.82
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.53   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.53   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Disease
Reactome
EGFR downregulation
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Disease
EGFR downregulation
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (218)
1 – 10 of 218
HGS
Tbio
Family: Enzyme
Novelty: 0.00097717
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
TRAF7
Tbio
Family: Enzyme
Novelty: 0.05310289
p_int: 0.985238624
p_ni: 0.014761375
p_wrong: 1e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
NCEH1
Tchem
Family: Enzyme
Novelty: 0.02418747
p_int: 0.980936456
p_ni: 0.018293593
p_wrong: 0.000769951
Score: 0.173
Data Source: BioPlex,STRINGDB
SNX1
Tbio
Novelty: 0.01941208
p_int: 0.767232784
p_ni: 0.203368634
p_wrong: 0.029398582
Score: 0.593
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00161137
Score: 0.997
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.996
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.995
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00895161
Score: 0.995
Data Source: STRINGDB
STAMBP
Tbio
Novelty: 0.02642988
Score: 0.992
Data Source: Reactome,STRINGDB
UBQLN2
Tbio
Novelty: 0.01042371
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.53

PubMed score by year
PubTator Score  70.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer