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Tbio
DPF1
Zinc finger protein neuro-d4

Protein Summary
Description
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355526
  • ENSP00000347716
  • ENSG00000011332
  • ENST00000412732
  • ENSP00000412098
  • ENST00000414789
  • ENSP00000391884
  • ENST00000420980
  • ENSP00000397354

Symbol
  • BAF45B
  • NEUD4
  • NEUD4
  • BAF45b
  • neuro-d4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.75
transcription factor
0.75
gene perturbation
0.58
small molecule perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (40)
1 – 10 of 40
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.99999966
p_ni:  3.29e-7
p_wrong:  1.1e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999999003
p_ni:  9.95e-7
p_wrong:  2e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999998801
p_ni:  0.000001195
p_wrong:  5e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
SS18
Tbio
Novelty:  0.00915548
p_int:  0.999997833
p_ni:  0.00000206
p_wrong:  1.07e-7
Score:  0.935
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999996717
p_ni:  0.000003278
p_wrong:  5e-9
Score:  0.851
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.99999374
p_ni:  0.000006255
p_wrong:  4e-9
Score:  0.837
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999720017
p_ni:  0.000148867
p_wrong:  0.000131117
Score:  0.979
Data Source:  BioPlex,STRINGDB
ACTL6B
Tbio
Novelty:  0.05740204
Score:  0.945
Data Source:  STRINGDB
SMARCC1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00961765
Score:  0.913
Data Source:  STRINGDB
SMARCA4
Tchem
Family:  Epigenetic
Novelty:  0.00112496
Score:  0.906
Data Source:  STRINGDB
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
92.5
platelet count
2
2
2
85.2
calcium measurement
1
1
1
63.7
mathematical ability
2
2
2
63
serum gamma-glutamyl transferase measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
platelet count
2
85.2
calcium measurement
1
63.7
mathematical ability
2
63
serum gamma-glutamyl transferase measurement
1
59
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
double PHD fingers 1
VGNC:7555
748599
Macaque
double PHD fingers 1
719503
Mouse
MGI:1352748
29861
Rat
RGD:61868
50545
Dog
double PHD fingers 1
VGNC:40065
484535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
double PHD fingers 1
Macaque
double PHD fingers 1
Mouse
Rat
Dog
double PHD fingers 1
Publication Statistics
PubMed Score 12.29
PubMed score by year
PubTator Score 6.21
PubTator score by year