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Tbio
RDH5
11-cis retinol dehydrogenase

Protein Summary
Description
Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257895
  • ENSP00000257895
  • ENSG00000135437
  • ENST00000548082
  • ENSP00000447128

Symbol
  • HSD17B9
  • RDH1
  • SDR9C5
  • RDH1
  • 9cRDH
  • SDR9C5
  • HSD17B9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
cell type or tissue
0.68
cellular component
0.68
tissue sample
0.57
transcription factor
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.9   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.9   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
3
13.8
96.4
Myopia
3
2
0
1.3
93
age at onset
1
1
0
13.8
83.1
Abnormality of refraction
1
1
1
53.3
atrophic macular degeneration
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
13.8
96.4
Myopia
0
1.3
93
age at onset
0
13.8
83.1
Abnormality of refraction
1
53.3
atrophic macular degeneration
0
1.2
30.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
retinol dehydrogenase 5 [Source:HGNC Symbol;Acc:HGNC:9940]
Mouse
MGI:1201412
19682
Rat
RGD:1308849
366791
Dog
retinol dehydrogenase 5
VGNC:45454
481098
Horse
retinol dehydrogenase 5
VGNC:22281
100051379
Species
Name
OMA
EggNOG
Inparanoid
Macaque
retinol dehydrogenase 5 [Source:HGNC Symbol;Acc:HGNC:9940]
Mouse
Rat
Dog
retinol dehydrogenase 5
Horse
retinol dehydrogenase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92781-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (72)
1 – 10 of 72
NME2P1
Tdark
Family:  Kinase
p_int:  0.975931053
p_ni:  0.024068947
Data Source:  BioPlex
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.954156095
p_ni:  0.045843905
Score:  0.455
Data Source:  BioPlex,STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Score:  0.403
Data Source:  BioPlex,STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.983
Data Source:  Reactome,STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.982
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.975
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.954
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.943
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.914
Data Source:  STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.90

PubMed score by year
PubTator Score  66.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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