Tchem CDKL2 Cyclin-dependent kinase-like 2

Protein Summary

Description

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92772
• B2R695

Gene Name

• CDKL2

Ensembl ID

• ENST00000429927
• ENSP00000412365
• ENSG00000138769

Symbol

• P56
• KKIAMRE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
small molecule	0.92
histone modification site profile	0.85
virus perturbation	0.79
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase-like 2

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase-like 2

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdkl Family / Cyclin-dependent Kinase-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.48   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.48   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0