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Tchem
CDKL2
Cyclin-dependent kinase-like 2

Protein Summary
Description
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429927
  • ENSP00000412365
  • ENSG00000138769

Symbol
  • P56
  • KKIAMRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
small molecule
0.92
histone modification site profile
0.85
virus perturbation
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL574738
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
56.3
1
1
0
1.2
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
56.3
0
1.2
55.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Epithelial to mesenchymal transition in colorectal cancer
Name
Explore in Pharos
Explore in Source
Epithelial to mesenchymal transition in colorectal cancer
Protein-Protein Interactions (24)
1 – 10 of 24
HSP90AA4P
Tdark
p_int: 0.999153233
p_ni: 0.000846746
p_wrong: 2.1e-8
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.984742845
p_ni: 0.015257145
p_wrong: 9e-9
Data Source: BioPlex
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.913868731
p_ni: 0.086131269
Score: 0.243
Data Source: BioPlex,STRINGDB
CDK14
Tchem
Family: Kinase
Novelty: 0.02074169
p_int: 0.826747418
p_ni: 0.131795384
p_wrong: 0.041457198
Score: 0.311
Data Source: BioPlex,STRINGDB
STEAP4
Tbio
Family: Enzyme
Novelty: 0.01926607
Score: 0.633
Data Source: STRINGDB
TMEM138
Tdark
Novelty: 0.40357932
Score: 0.584
Data Source: STRINGDB
FGL1
Tbio
Novelty: 0.02650803
Score: 0.548
Data Source: STRINGDB
ZNF154
Tbio
Family: TF
Novelty: 0.1287115
Score: 0.536
Data Source: STRINGDB
ZSCAN30
Tdark
Family: TF
Novelty: 1.6056338
Score: 0.47
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.468
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.29

PubMed score by year
PubTator Score  112.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer