Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-m ...more
- ENST00000368632
- ENSP00000357621
- ENSG00000196591
- ENST00000519065
- ENSP00000430432
- ENST00000519108
- ENSP00000430008
- HD2
- RPD3
- YAF1
- KDAC2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
co-expressed gene | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
molecular function | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 932.2 (req: < 5)
Gene RIFs: 199 (req: <= 3)
Antibodies: 892 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 932.2 (req: >= 5)
Gene RIFs: 199 (req: > 3)
Antibodies: 892 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 62
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 979
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (979)
Protein-Protein Interactions (581)
MIER2
Novelty: 0.85226416
p_int: 0.99955284
p_ni: 0.00044716
Score: 0.619
Data Source: BioPlex,STRINGDB
HDAC1
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999396926
p_ni: 0.000603074
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
ZNF219
Family: TF
Novelty: 0.17515242
p_int: 0.99884662
p_ni: 0.00115338
Score: 0.74
Data Source: BioPlex,STRINGDB
MBD3L1
Novelty: 0.11297566
p_int: 0.998698444
p_ni: 0.001301556
Score: 0.801
Data Source: BioPlex,STRINGDB
SINHCAF
Novelty: 0.18692832
p_int: 0.997875698
p_ni: 0.002124302
Score: 0.94
Data Source: BioPlex,STRINGDB
RBBP7
Novelty: 0.01795364
p_int: 0.997508278
p_ni: 0.002491722
Score: 0.998
Data Source: BioPlex,STRINGDB
H2AFZ
Novelty: 0.00222512
p_int: 0.982759922
p_ni: 0.017240078
Score: 0.972
Data Source: BioPlex,STRINGDB
CDK2AP1
Family: Enzyme
Novelty: 0.01584718
p_int: 0.976836291
p_ni: 0.023163709
Score: 0.544
Data Source: BioPlex,STRINGDB
HMG20A
Family: TF
Novelty: 0.11994252
p_int: 0.970044567
p_ni: 0.029955433
Score: 0.581
Data Source: BioPlex,STRINGDB
HMG20B
Family: TF
Novelty: 0.05983143
p_int: 0.960757064
p_ni: 0.039242936
Score: 0.986
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (81)
Reactome (48)
KEGG (13)
PathwayCommons (11)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Death Receptor Signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Death Receptor Signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (72)
Functions (14)
Components (10)
Processes (48)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
household income | 2 | 1 | 2 | 35 | |||||
self reported educational attainment | 1 | 1 | 1 | 11.2 | |||||
mathematical ability | 1 | 1 | 1 | 2.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
household income | 2 | 35 | |||||
self reported educational attainment | 1 | 11.2 | |||||
mathematical ability | 1 | 2.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 2 | VGNC:11094 | 462950 | |||||
Mouse | MGI:1097691 | 15182 | ||||||
Rat | RGD:619976 | 84577 | ||||||
Dog | histone deacetylase 2 | VGNC:49101 | 475035 | |||||
Horse | histone deacetylase 2 | VGNC:51036 | 100072578 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone deacetylase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 2 | |||||
Horse | histone deacetylase 2 | |||||
Publication Statistics
PubMed Score 932.20
PubMed score by year
PubTator Score 589.80
PubTator score by year
Related Publications
Text Mined References (332)
GeneRif Annotations (199)
Items per page:
0 of 0
PMID | Year | Title |
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