Tclin HDAC2 Histone deacetylase 2

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q92769
• B3KRS5
• B4DL58
• E1P561
• Q5SRI8
• Q5SZ86
• Q8NEH4
• HD2

Gene Name

• HDAC2

Ensembl ID

• ENST00000368632
• ENSP00000357621
• ENSG00000196591
• ENST00000519065
• ENSP00000430432
• ENST00000519108
• ENSP00000430008

Symbol

• HD2
• RPD3
• YAF1
• KDAC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
co-expressed gene	1
hub protein	1
interacting protein	1
molecular function	1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Histone Deacetylase 2

Protein / Nucleic Acid Binding / Histone Deacetylase 2

Protein / Hydrolase / Deacetylase / Histone Deacetylase 2

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class I / Histone Deacetylase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1087.69   (req: < 5)

Gene RIFs: 271   (req: <= 3)

Antibodies: 892   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1087.69   (req: >= 5)

Gene RIFs: 271   (req: > 3)

Antibodies: 892   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1182

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6