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Tclin
HDAC2
Histone deacetylase 2

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368632
  • ENSP00000357621
  • ENSG00000196591
  • ENST00000519065
  • ENSP00000430432
  • ENST00000519108
  • ENSP00000430008

Symbol
  • HD2
  • RPD3
  • YAF1
  • KDAC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
co-expressed gene
1
hub protein
1
interacting protein
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 932.2   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 892   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 932.2   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 892   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 979
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (979)
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
CUDC-101
Rendered image for CUDC-101
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
dacinostat
Rendered image for dacinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
quisinostat
Rendered image for quisinostat
scriptaid
Rendered image for scriptaid
Protein-Protein Interactions (581)
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.99955284
p_ni:  0.00044716
Score:  0.619
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999396926
p_ni:  0.000603074
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.99884662
p_ni:  0.00115338
Score:  0.74
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.998698444
p_ni:  0.001301556
Score:  0.801
Data Source:  BioPlex,STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.997875698
p_ni:  0.002124302
Score:  0.94
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.997508278
p_ni:  0.002491722
Score:  0.998
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.982759922
p_ni:  0.017240078
Score:  0.972
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.976836291
p_ni:  0.023163709
Score:  0.544
Data Source:  BioPlex,STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.970044567
p_ni:  0.029955433
Score:  0.581
Data Source:  BioPlex,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.960757064
p_ni:  0.039242936
Score:  0.986
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (81)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Death Receptor Signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (72)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
2
1
2
35
self reported educational attainment
1
1
1
11.2
mathematical ability
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
2
35
self reported educational attainment
1
11.2
mathematical ability
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 2
VGNC:11094
462950
Mouse
MGI:1097691
15182
Rat
RGD:619976
84577
Dog
histone deacetylase 2
VGNC:49101
475035
Horse
histone deacetylase 2
VGNC:51036
100072578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 2
Mouse
Rat
Dog
histone deacetylase 2
Horse
histone deacetylase 2
Publication Statistics
PubMed Score 932.20
PubMed score by year
PubTator Score 589.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title