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Tbio
RREB1
Ras-responsive element-binding protein 1

Protein Summary
Description
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334984
  • ENSP00000335574
  • ENSG00000124782
  • ENST00000349384
  • ENSP00000305560
  • ENST00000379933
  • ENSP00000369265
  • ENST00000379938
  • ENSP00000369270

Symbol
  • FINB
  • HNT
  • FINB
  • LZ321
  • Zep-1
  • RREB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.95
transcription factor
0.95
transcription factor binding site profile
0.92
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.93   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.93   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
4
3
1.1
98.6
waist-hip ratio
4
2
4
96.7
urate measurement
2
2
3
96.6
sex hormone-binding globulin measurement
6
1
6
95.8
heel bone mineral density
3
2
5
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
98.6
waist-hip ratio
4
96.7
urate measurement
3
96.6
sex hormone-binding globulin measurement
6
95.8
heel bone mineral density
5
95.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras responsive element binding protein 1
VGNC:3690
462416
Macaque
ras responsive element binding protein 1
693556
Mouse
MGI:2443664
68750
Rat
RGD:1310904
306873
Dog
ras responsive element binding protein 1
VGNC:45758
488206
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras responsive element binding protein 1
Macaque
ras responsive element binding protein 1
Mouse
Rat
Dog
ras responsive element binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92766-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999986
p_ni: 3e-9
p_wrong: 1.1e-8
Score: 0.406
Data Source: BioPlex,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.99996202
p_ni: 1.41e-7
p_wrong: 0.000037839
Score: 0.571
Data Source: BioPlex,STRINGDB
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
p_int: 0.999854413
p_ni: 0.000129204
p_wrong: 0.000016383
Data Source: BioPlex
SPATA20
Tdark
Novelty: 0.34126403
p_int: 0.965059265
p_ni: 0.001788057
p_wrong: 0.033152678
Score: 0.235
Data Source: BioPlex,STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
Score: 0.696
Data Source: STRINGDB
SLC39A1
Tbio
Family: Transporter
Novelty: 0.00678191
Score: 0.691
Data Source: STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
Score: 0.689
Data Source: STRINGDB
SLC16A9
Tbio
Family: Transporter
Novelty: 0.06564904
Score: 0.685
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.64
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.64
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.93

PubMed score by year
PubTator Score  55.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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