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Tbio
FRZB
Secreted frizzled-related protein 3

Protein Summary
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295113
  • ENSP00000295113
  • ENSG00000162998

Symbol
  • FIZ
  • FRE
  • FRP
  • FRZB1
  • SFRP3
  • FRE
  • OS1
  • FZRB
  • hFIZ
  • FRITZ
  • FRP-3
  • FRZB1
  • SFRP3
  • SRFP3
  • FRZB-1
  • FRZB-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
protein domain
0.85
gene perturbation
0.76
virus perturbation
0.76
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.81   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.81   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
WNT1
Tbio
Novelty:  0.00124301
Score:  0.847
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.844
Data Source:  STRINGDB
MATN3
Tbio
Novelty:  0.00426202
Score:  0.8
Data Source:  STRINGDB
DKK1
Tchem
Novelty:  0.00117121
Score:  0.773
Data Source:  STRINGDB
WIF1
Tbio
Novelty:  0.00548622
Score:  0.761
Data Source:  STRINGDB
WNT8A
Tbio
Novelty:  0.01404009
Score:  0.761
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.753
Data Source:  STRINGDB
WNT11
Tbio
Novelty:  0.0045754
Score:  0.742
Data Source:  STRINGDB
WNT9A
Tbio
Novelty:  0.01259196
Score:  0.736
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Wnt signaling pathway
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )
Name
Explore in Pharos
Explore in Source
Wnt signaling pathway
Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
70.9
self reported educational attainment
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
70.9
self reported educational attainment
1
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled related protein
VGNC:434
742552
Macaque
frizzled related protein
706048
Mouse
MGI:892032
20378
Rat
RGD:1311315
295691
Dog
frizzled related protein
VGNC:53094
478827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled related protein
Macaque
frizzled related protein
Mouse
Rat
Dog
frizzled related protein
Publication Statistics
PubMed Score 412.81
PubMed score by year
PubTator Score 294.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title