Tbio KRT35 Keratin, type I cuticular Ha5

Protein Summary

Description

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92764
• O76012
• Q92651

Gene Name

• KRT35

Ensembl ID

• ENST00000393989
• ENSP00000377558
• ENSG00000197079

Symbol

• HHA5
• HKA5
• KRTHA5
• HA5
• Ha-5
• hHa5
• KRTHA5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
interacting protein	0.71
protein domain	0.58
co-expressed gene	0.57
cell type or tissue	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.74   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.74   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0