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Tbio
TFAP2C
Transcription factor AP-2 gamma

Protein Classes
Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201031
  • ENSP00000201031
  • ENSG00000087510

Symbol
  • ERF1
  • TFAP2G
  • hAP-2g
  • AP2-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.88
molecular function
0.88
biological process
0.87
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.74   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.74   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (18)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (77)
1 – 10 of 77
KCTD1
Tbio
Novelty: 0.00271146
Score: 0.991
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00008166
Score: 0.979
Data Source: STRINGDB
CITED2
Tbio
Novelty: 0.0088691
Score: 0.967
Data Source: Reactome,STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.0030135
Score: 0.957
Data Source: Reactome,STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.000073
Score: 0.956
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.0000974
Score: 0.951
Data Source: STRINGDB
CITED1
Tbio
Novelty: 0.02087842
Score: 0.949
Data Source: STRINGDB
CITED4
Tbio
Novelty: 0.08180588
Score: 0.947
Data Source: Reactome,STRINGDB
KCTD15
Tbio
Novelty: 0.08567174
Score: 0.947
Data Source: Reactome,STRINGDB
TFAP2A
Tbio
Family: TF
Novelty: 0.0031574
Score: 0.945
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  82.74

PubMed score by year
PubTator Score  63.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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