Tbio TFAP2C Transcription factor AP-2 gamma

Protein Summary

Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92754
• B4DWK3
• O00685
• O00730
• Q86V30
• Q8IVB6
• Q9P1X2
• AP2-gamma

Gene Name

• TFAP2C

Ensembl ID

• ENST00000201031
• ENSP00000201031
• ENSG00000087510

Symbol

• ERF1
• TFAP2G
• hAP-2g
• AP2-GAMMA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.88
molecular function	0.88
biological process	0.87
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Ap-2 Gamma

DTO Classes

Protein / Transcription Factor / Transcription Factor Ap-2 Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.13   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.13   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0