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Tchem
RORB
Nuclear receptor ROR-beta

Protein Summary
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376896
  • ENSP00000366093
  • ENSG00000198963
  • ENST00000396204
  • ENSP00000379507

Symbol
  • NR1F2
  • RZRB
  • RZRB
  • EIG15
  • NR1F2
  • ROR-BETA
  • RZR-BETA
  • bA133M9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
gene perturbation
0.63
transcription factor
0.63
microRNA
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.94   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.94   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tretinoin
chemical structure image
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (25)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
MED1
Tbio
Family: Enzyme
Novelty: 0.01259825
Score: 0.904
Data Source: STRINGDB
RORC
Tchem
Family: NR
Novelty: 0.00579883
Score: 0.849
Data Source: STRINGDB
BHLHE40
Tbio
Family: TF
Novelty: 0.01475643
Score: 0.824
Data Source: STRINGDB
PER3
Tbio
Novelty: 0.00506928
Score: 0.806
Data Source: STRINGDB
NFIL3
Tbio
Family: TF
Novelty: 0.01158727
Score: 0.806
Data Source: STRINGDB
RORA
Tchem
Family: NR
Novelty: 0.00528528
Score: 0.805
Data Source: STRINGDB
BHLHE41
Tbio
Family: TF
Novelty: 0.00847455
Score: 0.804
Data Source: STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.01102244
Score: 0.795
Data Source: STRINGDB
CRY1
Tchem
Novelty: 0.00172273
Score: 0.795
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00211154
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score  78.94

PubMed score by year
PubTator Score  36.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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