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Tchem
RORB
Nuclear receptor ROR-beta

Protein Summary
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376896
  • ENSP00000366093
  • ENSG00000198963
  • ENST00000396204
  • ENSP00000379507

Symbol
  • NR1F2
  • RZRB
  • RZRB
  • EIG15
  • NR1F2
  • ROR-BETA
  • RZR-BETA
  • bA133M9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
gene perturbation
0.63
transcription factor
0.63
microRNA
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.27   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.27   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (59)
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.904
Data Source:  STRINGDB
RORC
Tchem
Family:  NR
Novelty:  0.00509106
Score:  0.849
Data Source:  STRINGDB
BHLHE40
Tbio
Family:  TF
Novelty:  0.01175662
Score:  0.824
Data Source:  STRINGDB
PER3
Tbio
Novelty:  0.00350199
Score:  0.806
Data Source:  STRINGDB
NFIL3
Tbio
Family:  TF
Novelty:  0.00882074
Score:  0.806
Data Source:  STRINGDB
RORA
Tchem
Family:  NR
Novelty:  0.00405767
Score:  0.805
Data Source:  STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.804
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.795
Data Source:  STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.795
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
91.6
reticulocyte measurement
3
2
3
68
viral load
1
1
1
66
refractive error measurement
2
1
1
6.8
65.5
Myopia
1
1
0
6.8
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
91.6
reticulocyte measurement
3
68
viral load
1
66
refractive error measurement
1
6.8
65.5
Myopia
0
6.8
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAR related orphan receptor B
VGNC:9219
472956
Macaque
RAR related orphan receptor B
703310
Mouse
MGI:1343464
225998
Rat
RGD:1306778
309288
Dog
RAR related orphan receptor B
VGNC:45696
484164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAR related orphan receptor B
Macaque
RAR related orphan receptor B
Mouse
Rat
Dog
RAR related orphan receptor B
Publication Statistics
PubMed Score 105.27
PubMed score by year
PubTator Score 36.71
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title