Protein Summary
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiatio ...more
- ENST00000376896
- ENSP00000366093
- ENSG00000198963
- ENST00000396204
- ENSP00000379507
- NR1F2
- RZRB
- RZRB
- EIG15
- NR1F2
- ROR-BETA
- RZR-BETA
- bA133M9.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.98 | ||
gene perturbation | 0.63 | ||
transcription factor | 0.63 | ||
microRNA | 0.58 | ||
tissue sample | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.94 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 357 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.94 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 357 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (4)
1 – 4 of 4
Pathways (11)
Reactome (4)
KEGG (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Nuclear Receptor transcription pathway | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (25)
Functions (9)
Components (2)
Processes (14)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (59)
1 – 10 of 59
MED1
Family: Enzyme
Novelty: 0.01259825
Score: 0.904
Data Source: STRINGDB
RORC
Family: NR
Novelty: 0.00579883
Score: 0.849
Data Source: STRINGDB
BHLHE40
Family: TF
Novelty: 0.01475643
Score: 0.824
Data Source: STRINGDB
PER3
Novelty: 0.00506928
Score: 0.806
Data Source: STRINGDB
NFIL3
Family: TF
Novelty: 0.01158727
Score: 0.806
Data Source: STRINGDB
RORA
Family: NR
Novelty: 0.00528528
Score: 0.805
Data Source: STRINGDB
BHLHE41
Family: TF
Novelty: 0.00847455
Score: 0.804
Data Source: STRINGDB
NPAS2
Family: TF
Novelty: 0.01102244
Score: 0.795
Data Source: STRINGDB
CRY1
Novelty: 0.00172273
Score: 0.795
Data Source: STRINGDB
CLOCK
Family: TF; Epigenetic
Novelty: 0.00211154
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score 78.94
PubMed score by year
PubTator Score 36.71
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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