Protein Summary
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiatio ...more
- ENST00000376896
- ENSP00000366093
- ENSG00000198963
- ENST00000396204
- ENSP00000379507
- NR1F2
- RZRB
- RZRB
- EIG15
- NR1F2
- ROR-BETA
- RZR-BETA
- bA133M9.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.98 | ||
gene perturbation | 0.63 | ||
transcription factor | 0.63 | ||
microRNA | 0.58 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.27 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 357 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.27 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 357 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 27
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (27)
Protein-Protein Interactions (59)
Nearest Tclin Targets
Pathways (11)
Reactome (4)
KEGG (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Nuclear Receptor transcription pathway | ||||
RNA Polymerase II Transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (9)
Components (2)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 2 | 3 | 91.6 | |||||
reticulocyte measurement | 3 | 2 | 3 | 68 | |||||
viral load | 1 | 1 | 1 | 66 | |||||
refractive error measurement | 2 | 1 | 1 | 6.8 | 65.5 | ||||
Myopia | 1 | 1 | 0 | 6.8 | 50.6 | ||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 91.6 | |||||
reticulocyte measurement | 3 | 68 | |||||
viral load | 1 | 66 | |||||
refractive error measurement | 1 | 6.8 | 65.5 | ||||
Myopia | 0 | 6.8 | 50.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RAR related orphan receptor B | VGNC:9219 | 472956 | |||||
Macaque | RAR related orphan receptor B | 703310 | ||||||
Mouse | MGI:1343464 | 225998 | ||||||
Rat | RGD:1306778 | 309288 | ||||||
Dog | RAR related orphan receptor B | VGNC:45696 | 484164 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RAR related orphan receptor B | |||||
Macaque | RAR related orphan receptor B | |||||
Mouse | ||||||
Rat | ||||||
Dog | RAR related orphan receptor B | |||||
Publication Statistics
PubMed Score 105.27
PubMed score by year
PubTator Score 36.71
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (30)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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