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Tbio
TNR
Tenascin-R

Protein Summary
Description
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263525
  • ENSP00000263525
  • ENSG00000116147
  • ENST00000367674
  • ENSP00000356646

Symbol
  • TN-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.82
disease
0.69
gene perturbation
0.67
cell type or tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
1
1
53.3
1
1
0
1.5
21.5
disease progression measurement
1
1
0
1.5
21.5
testosterone measurement
1
1
1
17.8
intelligence
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
53.3
0
1.5
21.5
disease progression measurement
0
1.5
21.5
testosterone measurement
1
17.8
intelligence
1
17.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tenascin R
VGNC:1694
469594
Macaque
tenascin R
708707
Mouse
MGI:99516
21960
Rat
RGD:3886
25567
Dog
tenascin R
VGNC:47697
490334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tenascin R
Macaque
tenascin R
Mouse
Rat
Dog
tenascin R
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92752-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (44)
1 – 10 of 44
ACAN
Tbio
Novelty:  0.00033695
Score:  0.982
Data Source:  Reactome,STRINGDB
BCAN
Tbio
Novelty:  0.00737982
Score:  0.951
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.944
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.943
Data Source:  STRINGDB
ITGA8
Tbio
Novelty:  0.0220023
Score:  0.831
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.831
Data Source:  STRINGDB
ITGA9
Tbio
Novelty:  0.01488635
Score:  0.831
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.813
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.807
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.807
Data Source:  STRINGDB
Publication Statistics
PubMed Score  22.74

PubMed score by year
PubTator Score  129.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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