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Tbio
ARPC1A
Actin-related protein 2/3 complex subunit 1A

Protein Summary
Description
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262942
  • ENSP00000262942
  • ENSG00000241685

Symbol
  • SOP2L
  • Arc40
  • SOP2L
  • HEL-68
  • SOP2Hs
  • HEL-S-307
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
hub protein
0.79
protein domain
0.73
virus perturbation
0.72
tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
80.6
hormone measurement
1
1
1
79.1
lymphocyte count
1
1
1
76.4
ticagrelor measurement
1
1
1
62.8
acute coronary syndrome
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
80.6
hormone measurement
1
79.1
lymphocyte count
1
76.4
ticagrelor measurement
1
62.8
acute coronary syndrome
1
62.8
Pathways (27)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (296)
1 – 10 of 296
ACTR3B
Tbio
Novelty: 0.06033214
p_int: 0.999999707
p_ni: 2.93e-7
Score: 0.981
Data Source: BioPlex,STRINGDB
NCAPD2
Tbio
Novelty: 0.04960987
p_int: 0.99997106
p_ni: 0.000028879
p_wrong: 6.1e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
NCAPG
Tbio
Novelty: 0.01777557
p_int: 0.999961587
p_ni: 0.000038412
Score: 0.252
Data Source: BioPlex,STRINGDB
ACTR3
Tbio
Novelty: 0.02112745
p_int: 0.999524435
p_ni: 0.000475565
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5
Tbio
Novelty: 0.03434234
p_int: 0.998625616
p_ni: 0.001374384
Score: 0.999
Data Source: BioPlex,STRINGDB
NCAPH
Tbio
Novelty: 0.01598076
p_int: 0.998536716
p_ni: 0.001463284
Score: 0.221
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
p_int: 0.997610987
p_ni: 0.002389013
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC2
Tbio
Novelty: 0.02478791
p_int: 0.992886368
p_ni: 0.007113631
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC3
Tbio
Novelty: 0.02951522
p_int: 0.892703569
p_ni: 0.107296431
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5L
Tdark
Novelty: 0.35566409
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.05

PubMed score by year
PubTator Score  5.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer