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Tbio
USP6NL
USP6 N-terminal-like protein

Protein Summary
Description
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277575
  • ENSP00000277575
  • ENSG00000148429
  • ENST00000609104
  • ENSP00000476462

Symbol
  • KIAA0019
  • RNTRE
  • TRE2NL
  • USP6NL-IT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor
0.77
virus perturbation
0.76
histone modification site profile
0.75
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
p_int:  0.997365975
p_ni:  0.002260072
p_wrong:  0.000373954
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.994143888
p_ni:  0.005822999
p_wrong:  0.000033113
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.986730289
p_ni:  0.012225276
p_wrong:  0.001044435
Data Source:  BioPlex
HIST1H1B
Tbio
Novelty:  0.00193344
p_int:  0.978899599
p_ni:  0.020838463
p_wrong:  0.000261938
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.905991824
p_ni:  0.094008174
p_wrong:  1e-9
Data Source:  BioPlex
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.902949489
p_ni:  0.096827685
p_wrong:  0.000222826
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.893869264
p_ni:  0.106130725
p_wrong:  1.1e-8
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.834422516
p_ni:  0.165576902
p_wrong:  5.82e-7
Data Source:  BioPlex
EPS8
Tbio
Family:  Enzyme
Novelty:  0.01023541
Score:  0.996
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
29.9
late-onset Alzheimers disease
1
1
0
1.1
9
family history of Alzheimer’s disease
1
1
0
5.7
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
29.9
late-onset Alzheimers disease
0
1.1
9
family history of Alzheimer’s disease
0
5.7
1.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
USP6 N-terminal like
VGNC:5874
466011
Macaque
USP6 N-terminal like
694275
Mouse
MGI:2138893
98910
Rat
RGD:1311786
291309
Dog
USP6 N-terminal like
VGNC:48204
487132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
USP6 N-terminal like
Macaque
USP6 N-terminal like
Mouse
Rat
Dog
USP6 N-terminal like
Publication Statistics
PubMed Score 10.56
PubMed score by year
PubTator Score 6.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title