Protein Summary
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided ...more
- ENST00000366574
- ENSP00000355533
- ENSG00000198626
- RyR
- ARVC2
- ARVD2
- RYR-2
- VTSIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
protein domain | 1 | ||
trait | 1 | ||
cellular component | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1449.9 (req: < 5)
Gene RIFs: 146 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1449.9 (req: >= 5)
Gene RIFs: 146 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 53
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (53)
Protein-Protein Interactions (217)
Nearest Tclin Targets
Pathways (24)
Reactome (6)
KEGG (12)
PathwayCommons (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Ion channel transport | ||||
Reactome | Ion homeostasis | ||||
Reactome | Muscle contraction | ||||
Reactome | Stimuli-sensing channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Ion channel transport | ||||
Ion homeostasis | ||||
Muscle contraction | ||||
Stimuli-sensing channels | ||||
Viral Interactions (0)
Gene Ontology Terms (66)
Functions (13)
Components (11)
Processes (42)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 1 | 2 | 49.5 | |||||
risk-taking behaviour | 1 | 2 | 2 | 45.6 | |||||
forced expiratory volume | 1 | 1 | 0 | 52.2 | 15.8 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 49.5 | |||||
risk-taking behaviour | 2 | 45.6 | |||||
forced expiratory volume | 0 | 52.2 | 15.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ryanodine receptor 2 | VGNC:6990 | 457846 | |||||
Macaque | ryanodine receptor 2 | 717179 | ||||||
Mouse | MGI:99685 | 20191 | ||||||
Rat | RGD:620314 | 689560 | ||||||
Dog | ryanodine receptor 2 | VGNC:45822 | 403615 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ryanodine receptor 2 | |||||
Macaque | ryanodine receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ryanodine receptor 2 | |||||
Publication Statistics
PubMed Score 1449.90
PubMed score by year
PubTator Score 707.28
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (200)
GeneRif Annotations (146)
Items per page:
0 of 0
PMID | Year | Title |
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