Protein Classes
Protein Summary
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided ...more
- ENST00000366574
- ENSP00000355533
- ENSG00000198626
- RyR
- ARVC2
- ARVD2
- RYR-2
- VTSIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
protein domain | 1 | ||
trait | 1 | ||
cellular component | 0.92 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1407.84 (req: < 5)
Gene RIFs: 146 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1407.84 (req: >= 5)
Gene RIFs: 146 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 53
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (53)
1 – 10 of 53
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 1 | 2 | 79.2 | |||||
risk-taking behaviour | 1 | 2 | 2 | 24.1 | |||||
forced expiratory volume | 1 | 1 | 0 | 52.2 | 18.4 | ||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 79.2 | |||||
risk-taking behaviour | 2 | 24.1 | |||||
forced expiratory volume | 0 | 52.2 | 18.4 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ryanodine receptor 2 | VGNC:6990 | 457846 | |||||
Macaque | ryanodine receptor 2 | 717179 | ||||||
Mouse | MGI:99685 | 20191 | ||||||
Rat | RGD:620314 | 689560 | ||||||
Dog | ryanodine receptor 2 | VGNC:45822 | 403615 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ryanodine receptor 2 | |||||
Macaque | ryanodine receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ryanodine receptor 2 | |||||
Protein Structure (1 Structure, 19 AlphaFold Models)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (24)
Reactome (6)
KEGG (12)
PathwayCommons (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Ion channel transport | ||||
Reactome | Ion homeostasis | ||||
Reactome | Muscle contraction | ||||
Reactome | Stimuli-sensing channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Ion channel transport | ||||
Ion homeostasis | ||||
Muscle contraction | ||||
Stimuli-sensing channels | ||||
Gene Ontology Terms (66)
Functions (13)
Components (11)
Processes (42)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (217)
1 – 10 of 217
FKBP1B
Family: Enzyme
Novelty: 0.00541222
Score: 0.999
Data Source: STRINGDB
TRDN
Novelty: 0.00501554
Score: 0.988
Data Source: STRINGDB
CALM1
Novelty: 0.00308267
Score: 0.985
Data Source: STRINGDB
ASPH
Family: Enzyme
Novelty: 0.00291455
Score: 0.982
Data Source: STRINGDB
CAMK2D
Family: Kinase
Novelty: 0.02326864
Score: 0.955
Data Source: STRINGDB
NOS1
Family: Enzyme
Novelty: 0.00032064
Score: 0.926
Data Source: STRINGDB
PPP1CC
Family: Enzyme
Novelty: 0.00465946
Score: 0.926
Data Source: STRINGDB
CASQ2
Novelty: 0.00775794
Score: 0.915
Data Source: STRINGDB
CALM3
Novelty: 0.00461552
Score: 0.911
Data Source: STRINGDB
RAPGEF4
Novelty: 0.00235788
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score 1407.84
PubMed score by year
PubTator Score 707.28
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword