Tclin RYR2 Ryanodine receptor 2

Protein Summary

Description

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92736
• Q15411
• Q546N8
• Q5T3P2
• RYR-2

Gene Name

• RYR2

Ensembl ID

• ENST00000366574
• ENSP00000355533
• ENSG00000198626

Symbol

• RyR
• ARVC2
• ARVD2
• RYR-2
• VTSIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	1
trait	1
cellular component	0.92

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Ryanodine Receptor 2

Protein / Receptor / Ligand-gated Ion Channel / Ryanodine Receptor 2

DTO Classes

Protein / Ion Channel / Ryanodine-inositol 1,4,5-triphosphate Receptor Calcium Channel (Rir-cac) Family / Ryr2 Subfamily / Ryanodine Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1647.64   (req: < 5)

Gene RIFs: 196   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1647.64   (req: >= 5)

Gene RIFs: 196   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2