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Tbio
TFG
Protein TFG

Protein Summary
Description
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240851
  • ENSP00000240851
  • ENSG00000114354
  • ENST00000418917
  • ENSP00000397182
  • ENST00000476228
  • ENSP00000417952
  • ENST00000490574
  • ENSP00000419960
  • ENST00000615993
  • ENSP00000479269
  • ENST00000620299
  • ENSP00000479981

Symbol
  • TF6
  • HMSNP
  • SPG57
  • TRKT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
disease perturbation
0.9
drug perturbation
0.87
transcription factor perturbation
0.84
hub protein
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.74   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.74   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
15.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRK-fused gene
460557
Macaque
TRK-fused gene
700972
Mouse
MGI:1338041
21787
Rat
RGD:1309751
360709
Dog
TRK-fused gene
VGNC:47299
487954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRK-fused gene
Macaque
TRK-fused gene
Mouse
Rat
Dog
TRK-fused gene
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92734-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (110)
1 – 10 of 110
SPINK5
Tbio
Family:  Enzyme
Novelty:  0.00451563
p_int:  0.99999984
p_ni:  1.25e-7
p_wrong:  3.5e-8
Score:  0.403
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.999794577
p_ni:  0.000205423
Data Source:  BioPlex
SEC31A
Tbio
Novelty:  0.0350228
p_int:  0.999660019
p_ni:  0.000339981
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.999636392
p_ni:  0.000363424
p_wrong:  1.84e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.99494802
p_ni:  0.005051978
p_wrong:  2e-9
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.993816144
p_ni:  0.006183856
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.982012934
p_ni:  0.017987066
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.978571125
p_ni:  0.021428875
Data Source:  BioPlex
HNRNPCL1
Tdark
Novelty:  1.05199828
p_int:  0.974690834
p_ni:  0.025309166
Score:  0.261
Data Source:  BioPlex,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.928268239
p_ni:  0.071731761
Score:  0.949
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  66.74

PubMed score by year
PubTator Score  72.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer