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Tclin
ESR2
Estrogen receptor beta

Protein Summary
Description
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267525
  • ENSP00000267525
  • ENSG00000140009
  • ENST00000341099
  • ENSP00000343925
  • ENST00000344288
  • ENSP00000345616
  • ENST00000353772
  • ENSP00000335551
  • ENST00000358599
  • ENSP00000351412
  • ENST00000553796
  • ENSP00000452426
  • ENST00000554572
  • ENSP00000450699
  • ENST00000555278
  • ENSP00000450488
  • ENST00000557772
  • ENSP00000451582

Symbol
  • ESTRB
  • NR3A2
  • Erb
  • ESRB
  • ODG8
  • ESTRB
  • NR3A2
  • ER-BETA
  • ESR-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
hub protein
1
molecular function
1
drug
0.97
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4380   (req: < 5)
Gene RIFs: 901   (req: <= 3)
Antibodies: 1609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4380   (req: >= 5)
Gene RIFs: 901   (req: > 3)
Antibodies: 1609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1020
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (211)
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.994
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.976
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.971
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.971
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.967
Data Source:  STRINGDB
NOS3
Tchem
Family:  Enzyme
Novelty:  0.00012407
Score:  0.967
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.965
Data Source:  STRINGDB
NR0B2
Tchem
Family:  NR
Novelty:  0.0009861
Score:  0.962
Data Source:  STRINGDB
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
Score:  0.961
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.959
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
ESR-mediated signaling
Extra-nuclear estrogen signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
90.4
hemoglobin measurement
3
1
3
83
hematocrit
4
1
4
82.8
red blood cell density measurement
1
1
1
80.8
3
2
0
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.4
hemoglobin measurement
3
83
hematocrit
4
82.8
red blood cell density measurement
1
80.8
0
1
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor 2
VGNC:9049
452964
Macaque
estrogen receptor 2
574110
Mouse
MGI:109392
13983
Rat
RGD:2582
25149
Dog
estrogen receptor 2
VGNC:40477
403639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor 2
Macaque
estrogen receptor 2
Mouse
Rat
Dog
estrogen receptor 2
Publication Statistics
PubMed Score 4380.00
PubMed score by year
PubTator Score 3171.86
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title