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Tbio
RND1
Rho-related GTP-binding protein Rho6

Protein Summary
Description
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309739
  • ENSP00000308461
  • ENSG00000172602

Symbol
  • RHO6
  • ARHS
  • RHO6
  • RHOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor binding site profile
0.8
histone modification site profile
0.76
virus perturbation
0.72
disease
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.997
Data Source:  Reactome,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
Score:  0.993
Data Source:  Reactome,STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.985
Data Source:  Reactome,STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.981
Data Source:  Reactome,STRINGDB
SEMA4D
Tbio
Novelty:  0.0043592
Score:  0.974
Data Source:  Reactome,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.958
Data Source:  STRINGDB
PLXNA4
Tbio
Novelty:  0.01807048
Score:  0.952
Data Source:  Reactome,STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.952
Data Source:  STRINGDB
PLXNA3
Tbio
Novelty:  0.02016528
Score:  0.952
Data Source:  Reactome,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
Score:  0.95
Data Source:  Reactome,STRINGDB
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Sema4D in semaphorin signaling
Reactome
Sema4D induced cell migration and growth-cone collapse
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
73.4
bone density
1
1
2
49.5
testosterone measurement
1
1
1
28.1
self reported educational attainment
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
73.4
bone density
2
49.5
testosterone measurement
1
28.1
self reported educational attainment
1
4.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho family GTPase 1
VGNC:5572
466975
Mouse
MGI:2444878
223881
Rat
RGD:1306338
362993
Dog
Rho family GTPase 1
VGNC:45616
477623
Horse
Rho family GTPase 1
VGNC:22421
100058747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho family GTPase 1
Mouse
Rat
Dog
Rho family GTPase 1
Horse
Rho family GTPase 1
Publication Statistics
PubMed Score 105.43
PubMed score by year
PubTator Score 30.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title