RND1
Rho-related GTP-binding protein Rho6
Protein Summary
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
- ENST00000309739
- ENSP00000308461
- ENSG00000172602
- RHO6
- ARHS
- RHO6
- RHOS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
transcription factor binding site profile | 0.8 | ||
histone modification site profile | 0.76 | ||
virus perturbation | 0.72 | ||
disease | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.43 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 119 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.43 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 119 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (133)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (13)
Reactome (7)
KEGG (1)
PathwayCommons (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Reactome | Sema4D in semaphorin signaling | ||||
Reactome | Sema4D induced cell migration and growth-cone collapse | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Sema4D in semaphorin signaling | ||||
Sema4D induced cell migration and growth-cone collapse | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (4)
Components (8)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 73.4 | |||||
bone density | 1 | 1 | 2 | 49.5 | |||||
testosterone measurement | 1 | 1 | 1 | 28.1 | |||||
self reported educational attainment | 1 | 1 | 1 | 4.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 73.4 | |||||
bone density | 2 | 49.5 | |||||
testosterone measurement | 1 | 28.1 | |||||
self reported educational attainment | 1 | 4.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Rho family GTPase 1 | VGNC:5572 | 466975 | |||||
Mouse | MGI:2444878 | 223881 | ||||||
Rat | RGD:1306338 | 362993 | ||||||
Dog | Rho family GTPase 1 | VGNC:45616 | 477623 | |||||
Horse | Rho family GTPase 1 | VGNC:22421 | 100058747 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Rho family GTPase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Rho family GTPase 1 | |||||
Horse | Rho family GTPase 1 | |||||
Publication Statistics
PubMed Score 105.43
PubMed score by year
PubTator Score 30.38
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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