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Tbio
RAD54L
DNA repair and recombination protein RAD54-like

Protein Summary
Description
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371975
  • ENSP00000361043
  • ENSG00000085999
  • ENST00000442598
  • ENSP00000396113

Symbol
  • RAD54A
  • HR54
  • hHR54
  • RAD54A
  • hRAD54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.91
histone modification site profile
0.9
gene perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (270)
1 – 10 of 270
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 1
Score: 0.224
Data Source: BioPlex,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.983
Data Source: STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.943
Data Source: STRINGDB
RAD52
Tbio
Novelty: 0.00125282
Score: 0.936
Data Source: STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.93
Data Source: STRINGDB
CDC45
Tbio
Novelty: 0.00515457
Score: 0.878
Data Source: STRINGDB
RAD51B
Tbio
Novelty: 0.00302521
Score: 0.864
Data Source: STRINGDB
RAD54B
Tbio
Novelty: 0.02431597
Score: 0.859
Data Source: STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.859
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
Score: 0.857
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.12

PubMed score by year
PubTator Score  79.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer