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Tdark
RABGGTA
Geranylgeranyl transferase type-2 subunit alpha

Protein Summary
Description
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216840
  • ENSP00000216840
  • ENSG00000100949
  • ENST00000399409
  • ENSP00000382341
  • ENST00000644383
  • ENSP00000494636
  • ENSG00000285193
  • ENST00000646658
  • ENSP00000496595

Symbol
  • PTAR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
kinase perturbation
0.84
histone modification site profile
0.83
disease perturbation
0.79
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rab geranylgeranyltransferase subunit alpha
VGNC:6799
452815
Macaque
Rab geranylgeranyltransferase alpha subunit
714521
Mouse
MGI:1860443
56187
Rat
RGD:621697
58983
Dog
Rab geranylgeranyltransferase subunit alpha
VGNC:45303
608407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rab geranylgeranyltransferase subunit alpha
Macaque
Rab geranylgeranyltransferase alpha subunit
Mouse
Rat
Dog
Rab geranylgeranyltransferase subunit alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92696-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (105)
1 – 10 of 105
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999999994
p_ni:  6e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
p_int:  0.999806698
p_ni:  0.000193302
Score:  0.981
Data Source:  BioPlex,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.999712239
p_ni:  0.000287761
Score:  0.95
Data Source:  BioPlex,STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.999559104
p_ni:  0.000440896
Score:  0.947
Data Source:  BioPlex,STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
p_int:  0.999465424
p_ni:  0.000534576
Score:  0.986
Data Source:  BioPlex,STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.999361973
p_ni:  0.000638027
Score:  0.979
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.998829999
p_ni:  0.001170001
Score:  0.926
Data Source:  BioPlex,STRINGDB
VPS25
Tbio
Novelty:  0.03002488
p_int:  0.998304497
p_ni:  0.001695503
Data Source:  BioPlex
RAB26
Tbio
Family:  Enzyme
Novelty:  0.12023869
p_int:  0.997948006
p_ni:  0.002051994
Score:  0.932
Data Source:  BioPlex,STRINGDB
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
p_int:  0.996633966
p_ni:  0.003366034
Score:  0.975
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.22

PubMed score by year
PubTator Score  4.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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