Tdark RABGGTA Geranylgeranyl transferase type-2 subunit alpha

Protein Summary

Description

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Uniprot Accession IDs

• Q92696
• A8K5N2
• D3DS69

Gene Name

• RABGGTA

Ensembl ID

• ENST00000216840
• ENSP00000216840
• ENSG00000100949
• ENST00000399409
• ENSP00000382341
• ENST00000644383
• ENSP00000494636
• ENSG00000285193
• ENST00000646658
• ENSP00000496595

Symbol

• PTAR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.91
kinase perturbation	0.84
histone modification site profile	0.83
disease perturbation	0.79
transcription factor binding site profile	0.77

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Geranylgeranyl Transferase Type-2 Subunit Alpha

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Geranylgeranyl Transferase Type-2 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0