Tbio NECTIN2 Nectin-2

Protein Summary

Description

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92692
• A8K5L5
• O75455
• Q6IBI6
• Q96J29

Gene Name

• NECTIN2

Ensembl ID

• ENST00000252483
• ENSP00000252483
• ENSG00000130202
• ENST00000252485
• ENSP00000252485

Symbol

• HVEB
• PRR2
• PVRL2
• HVEB
• PRR2
• CD112
• PVRL2
• PVRR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.19   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.19   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (113)

Explore Interacting Targets

1 – 10 of 113

• See Interactions on String-DB

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.999949974

p_ni:  0.000050026

Data Source:  BioPlex

NECTIN3

Tbio

Novelty:  0.01288113

p_int:  0.99437014

p_ni:  0.00562986

Score:  0.969

Data Source:  BioPlex,Reactome,STRINGDB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.994315315

p_ni:  0.005684685

Data Source:  BioPlex

SYPL2

Tdark

Novelty:  0.03928948

p_int:  0.973993129

p_ni:  0.026006871

Score:  0.163

Data Source:  BioPlex,STRINGDB

BTBD1

Tbio

Novelty:  0.19772296

p_int:  0.916094556

p_ni:  0.083905433

p_wrong:  1.1e-8

Data Source:  BioPlex

TBC1D22A

Tbio

Novelty:  0.46374046

p_int:  0.845577045

p_ni:  0.154422955

p_wrong:  1e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

SERPINA12

Tbio

Novelty:  0.00549132

p_int:  0.841293379

p_ni:  0.158693734

p_wrong:  0.000012886

Data Source:  BioPlex

NR2F6

Tbio

Family:  NR

Novelty:  0.02314124

p_int:  0.820579509

p_ni:  0.179404843

p_wrong:  0.000015648

Data Source:  BioPlex

PANK2

Tbio

Family:  Kinase

Novelty:  0.00465551

p_int:  0.805291531

p_ni:  0.194708468

p_wrong:  1e-9

Score:  0.219

Data Source:  BioPlex,STRINGDB

PICK1

Tbio

Novelty:  0.0058265

p_int:  0.804501895

p_ni:  0.195498105

Score:  0.399

Data Source:  BioPlex,STRINGDB

Pathways (166)

Reactome (8)

KEGG (2)

PathwayCommons (2)

WikiPathways (154)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270

Gene Ontology Terms (36)

Functions (5)

Components (8)

Processes (23)

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GO Term	Evidence	Assigned by
cell adhesion molecule binding	Inferred from Physical Interaction (IPI)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
coreceptor activity	Traceable Author Statement (TAS)	ProtInc
virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

GWAS Traits (122)

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1 – 5 of 122

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	35	77	116	8	100
apolipoprotein B measurement	EFO_0004615	2	68	69		100
total cholesterol measurement	EFO_0004574	21	64	94	6.8	100
C-reactive protein measurement	EFO_0004458	14	62	78	21.8	100
Alzheimer's disease	EFO_0000249	27	66	2	2.8	99.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 122

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	116	8	100
apolipoprotein B measurement	EFO_0004615	69		100
total cholesterol measurement	EFO_0004574	94	6.8	100
C-reactive protein measurement	EFO_0004458	78	21.8	100
Alzheimer's disease	EFO_0000249	2	2.8	99.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
age at onset
age-related macular degeneration
Agents acting on the renin-angiotensin system use measurement
alkaline phosphatase measurement
Alzheimer's disease
amyloid-beta measurement
Antithrombotic agent use measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nectin cell adhesion molecule 2	VGNC:7619	456118
Macaque	nectin cell adhesion molecule 2		713229
Mouse	nectin cell adhesion molecule 2	MGI:97822	19294
Rat	nectin cell adhesion molecule 2	RGD:1309505	308417
Dog	nectin cell adhesion molecule 2	VGNC:53741	611060

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nectin cell adhesion molecule 2
Macaque	nectin cell adhesion molecule 2
Mouse	nectin cell adhesion molecule 2
Rat	nectin cell adhesion molecule 2
Dog	nectin cell adhesion molecule 2

Publication Statistics

PubMed Score 105.19

PubMed score by year

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PubTator Score 76.55

PubTator score by year

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