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Tbio
NECTIN2
Nectin-2

Protein Summary
Description
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with diff ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252483
  • ENSP00000252483
  • ENSG00000130202
  • ENST00000252485
  • ENSP00000252485

Symbol
  • HVEB
  • PRR2
  • PVRL2
  • HVEB
  • PRR2
  • CD112
  • PVRL2
  • PVRR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.26   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 476   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.26   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
15
0
3.2
99.2
C-reactive protein measurement
1
3
3
98.6
low density lipoprotein cholesterol measurement
3
3
4
98.3
total cholesterol measurement
4
2
5
96.8
family history of Alzheimer’s disease
1
9
0
9.5
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.2
99.2
C-reactive protein measurement
3
98.6
low density lipoprotein cholesterol measurement
4
98.3
total cholesterol measurement
5
96.8
family history of Alzheimer’s disease
0
9.5
94.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 2
VGNC:7619
456118
Macaque
nectin cell adhesion molecule 2
713229
Mouse
MGI:97822
19294
Rat
RGD:1309505
308417
Dog
nectin cell adhesion molecule 2
VGNC:53741
611060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 2
Macaque
nectin cell adhesion molecule 2
Mouse
Rat
Dog
nectin cell adhesion molecule 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92692-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (166)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene Ontology Terms (36)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (113)
1 – 10 of 113
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999949974
p_ni: 0.000050026
Data Source: BioPlex
NECTIN3
Tbio
Novelty: 0.01288113
p_int: 0.99437014
p_ni: 0.00562986
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.994315315
p_ni: 0.005684685
Data Source: BioPlex
SYPL2
Tdark
Novelty: 0.03928948
p_int: 0.973993129
p_ni: 0.026006871
Score: 0.163
Data Source: BioPlex,STRINGDB
BTBD1
Tbio
Novelty: 0.19772296
p_int: 0.916094556
p_ni: 0.083905433
p_wrong: 1.1e-8
Data Source: BioPlex
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.845577045
p_ni: 0.154422955
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.841293379
p_ni: 0.158693734
p_wrong: 0.000012886
Data Source: BioPlex
NR2F6
Tbio
Family: NR
Novelty: 0.02314124
p_int: 0.820579509
p_ni: 0.179404843
p_wrong: 0.000015648
Data Source: BioPlex
PANK2
Tbio
Family: Kinase
Novelty: 0.00465551
p_int: 0.805291531
p_ni: 0.194708468
p_wrong: 1e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.804501895
p_ni: 0.195498105
Score: 0.399
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.26

PubMed score by year
PubTator Score  76.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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