Protein Summary
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with diff ...more
- ENST00000252483
- ENSP00000252483
- ENSG00000130202
- ENST00000252485
- ENSP00000252485
- HVEB
- PRR2
- PVRL2
- HVEB
- PRR2
- CD112
- PVRL2
- PVRR2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.26 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 476 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.26 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 476 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 15 | 0 | 3.2 | 99.2 | |||||
C-reactive protein measurement | 1 | 3 | 3 | 98.6 | |||||
low density lipoprotein cholesterol measurement | 3 | 3 | 4 | 98.3 | |||||
total cholesterol measurement | 4 | 2 | 5 | 96.8 | |||||
family history of Alzheimerâs disease | 1 | 9 | 0 | 9.5 | 94.8 | ||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 3.2 | 99.2 | |||||
C-reactive protein measurement | 3 | 98.6 | |||||
low density lipoprotein cholesterol measurement | 4 | 98.3 | |||||
total cholesterol measurement | 5 | 96.8 | |||||
family history of Alzheimerâs disease | 0 | 9.5 | 94.8 | ||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nectin cell adhesion molecule 2 | VGNC:7619 | 456118 | |||||
Macaque | nectin cell adhesion molecule 2 | 713229 | ||||||
Mouse | MGI:97822 | 19294 | ||||||
Rat | RGD:1309505 | 308417 | ||||||
Dog | nectin cell adhesion molecule 2 | VGNC:53741 | 611060 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nectin cell adhesion molecule 2 | |||||
Macaque | nectin cell adhesion molecule 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nectin cell adhesion molecule 2 | |||||
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (166)
Reactome (8)
KEGG (2)
PathwayCommons (2)
WikiPathways (154)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Gene Ontology Terms (36)
Functions (5)
Components (8)
Processes (23)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (113)
1 – 10 of 113
TMEM30B
Novelty: 0.26735006
p_int: 0.999949974
p_ni: 0.000050026
Data Source: BioPlex
NECTIN3
Novelty: 0.01288113
p_int: 0.99437014
p_ni: 0.00562986
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.994315315
p_ni: 0.005684685
Data Source: BioPlex
SYPL2
Novelty: 0.03928948
p_int: 0.973993129
p_ni: 0.026006871
Score: 0.163
Data Source: BioPlex,STRINGDB
BTBD1
Novelty: 0.19772296
p_int: 0.916094556
p_ni: 0.083905433
p_wrong: 1.1e-8
Data Source: BioPlex
TBC1D22A
Novelty: 0.46374046
p_int: 0.845577045
p_ni: 0.154422955
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
SERPINA12
Novelty: 0.00549132
p_int: 0.841293379
p_ni: 0.158693734
p_wrong: 0.000012886
Data Source: BioPlex
NR2F6
Family: NR
Novelty: 0.02314124
p_int: 0.820579509
p_ni: 0.179404843
p_wrong: 0.000015648
Data Source: BioPlex
PANK2
Family: Kinase
Novelty: 0.00465551
p_int: 0.805291531
p_ni: 0.194708468
p_wrong: 1e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
PICK1
Novelty: 0.0058265
p_int: 0.804501895
p_ni: 0.195498105
Score: 0.399
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 99.26
PubMed score by year
PubTator Score 76.55
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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GWAS Trait