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Tbio
ANP32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

Protein Summary
Description
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339399
  • ENSP00000345848
  • ENSG00000136938

Symbol
  • APRIL
  • PHAPI2
  • APRIL
  • SSP29
  • PHAPI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
transcription factor binding site profile
0.85
disease perturbation
0.83
ligand (protein) perturbation
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.68   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.68   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0