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Tbio
ANP32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

Protein Summary
Description
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339399
  • ENSP00000345848
  • ENSG00000136938

Symbol
  • APRIL
  • PHAPI2
  • APRIL
  • SSP29
  • PHAPI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
transcription factor binding site profile
0.85
disease perturbation
0.83
ligand (protein) perturbation
0.83
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.85   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
83.8
mean corpuscular hemoglobin concentration
1
1
1
83.1
platelet crit
2
2
2
83
red blood cell density measurement
1
1
1
81.3
mean platelet volume
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
83.8
mean corpuscular hemoglobin concentration
1
83.1
platelet crit
2
83
red blood cell density measurement
1
81.3
mean platelet volume
1
53.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acidic nuclear phosphoprotein 32 family member B
VGNC:4614
464605
Macaque
acidic nuclear phosphoprotein 32 family member B
715508
Mouse
MGI:1914878
67628
Rat
RGD:621285
170724
Dog
acidic nuclear phosphoprotein 32 family member B
VGNC:37933
474775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acidic nuclear phosphoprotein 32 family member B
Macaque
acidic nuclear phosphoprotein 32 family member B
Mouse
Rat
Dog
acidic nuclear phosphoprotein 32 family member B
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92688-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (44)
1 – 10 of 44
VPS72
Tbio
Novelty:  0.00561093
Score:  0.902
Data Source:  STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
Score:  0.885
Data Source:  STRINGDB
ANP32A
Tbio
Novelty:  0.00567095
Score:  0.845
Data Source:  STRINGDB
KPNA5
Tbio
Novelty:  0.0762372
Score:  0.729
Data Source:  STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
Score:  0.711
Data Source:  STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.689
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.68
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.643
Data Source:  STRINGDB
CORO2A
Tbio
Novelty:  0.03292199
Score:  0.632
Data Source:  STRINGDB
XPO1
Tclin
Novelty:  0.00078187
Score:  0.63
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.85

PubMed score by year
PubTator Score  11.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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