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Tbio
ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Protein Summary
Description
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397676
  • ENSP00000380793
  • ENSG00000214160
  • ENST00000445626
  • ENSP00000402744

Symbol
  • NOT
  • NOT56L
  • not
  • CDG1D
  • CDGS4
  • CDGS6
  • Not56
  • NOT56L
  • D16Ertd36e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.86
kinase perturbation
0.76
transcription factor
0.74
transcription factor perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.28   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.28   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ALG3, alpha-1,3- mannosyltransferase
703087
Mouse
MGI:1098592
208624
Rat
RGD:1306004
287983
Dog
ALG3, alpha-1,3- mannosyltransferase
VGNC:37798
478653
Horse
ALG3, alpha-1,3- mannosyltransferase
VGNC:15248
100059007
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ALG3, alpha-1,3- mannosyltransferase
Mouse
Rat
Dog
ALG3, alpha-1,3- mannosyltransferase
Horse
ALG3, alpha-1,3- mannosyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92685-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG3 causes ALG3-CDG (CDG-1d)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG3 causes ALG3-CDG (CDG-1d)
Disease
Diseases associated with N-glycosylation of proteins
Protein-Protein Interactions (105)
1 – 10 of 105
TSGA10IP
Tdark
Novelty: 20.75428866
p_int: 0.999999106
p_ni: 5.9e-7
p_wrong: 3.04e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
KLHL14
Tbio
Novelty: 0.1214402
p_int: 0.999995877
p_ni: 0.000004122
p_wrong: 2e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
GFAP
Tbio
Novelty: 0.00020932
p_int: 0.999448137
p_ni: 0.000551863
Score: 0.209
Data Source: BioPlex,STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.03330389
p_int: 0.927314777
p_ni: 0.072685223
Score: 0.187
Data Source: BioPlex,STRINGDB
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.776760312
p_ni: 0.223239635
p_wrong: 5.4e-8
Data Source: BioPlex
ALG9
Tbio
Family: Enzyme
Novelty: 0.02975572
Score: 0.993
Data Source: STRINGDB
ALG11
Tbio
Family: Enzyme
Novelty: 0.00872486
Score: 0.987
Data Source: STRINGDB
DPM1
Tbio
Family: Enzyme
Novelty: 0.01317862
Score: 0.98
Data Source: STRINGDB
ALG12
Tbio
Family: Enzyme
Novelty: 0.03785588
Score: 0.975
Data Source: STRINGDB
ALG6
Tbio
Family: Enzyme
Novelty: 0.02610188
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.28

PubMed score by year
PubTator Score  17.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer