You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RSC1A1
Regulatory solute carrier protein family 1 member 1

Protein Summary
Description
Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345034
  • ENSP00000341963
  • ENSG00000215695

Symbol
  • RS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
cell type or tissue
0.81
tissue sample
0.71
cell line
0.59
cellular component
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3526447
69994
Dog
regulator of solute carriers 1 [Source:HGNC Symbol;Acc:HGNC:10458]
Horse
regulator of solute carriers 1 [Source:HGNC Symbol;Acc:HGNC:10458]
Cow
protein DDI1 homolog 2
515551
Pig
regulator of solute carriers 1
396699
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
regulator of solute carriers 1 [Source:HGNC Symbol;Acc:HGNC:10458]
Horse
regulator of solute carriers 1 [Source:HGNC Symbol;Acc:HGNC:10458]
Cow
protein DDI1 homolog 2
Pig
regulator of solute carriers 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Digestion and absorption (R-HSA-8963743)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion and absorption
Reactome
Intestinal absorption
Reactome
Intestinal hexose absorption
Reactome
Organic cation transport
Reactome
Organic cation/anion/zwitterion transport
Name
Explore in Pharos
Explore in Source
Digestion and absorption
Intestinal absorption
Intestinal hexose absorption
Organic cation transport
Organic cation/anion/zwitterion transport
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (43)
1 – 10 of 43
ZG16B
Tbio
Novelty: 0.08792924
p_int: 0.999950806
p_ni: 1.04e-7
p_wrong: 0.00004909
Score: 0.187
Data Source: BioPlex,STRINGDB
DDI1
Tbio
Novelty: 0.02845222
p_int: 0.991252932
p_ni: 0.000004459
p_wrong: 0.008742609
Score: 0.61
Data Source: BioPlex,STRINGDB
SLC5A4
Tchem
Family: Transporter
Novelty: 0.00070175
Score: 0.801
Data Source: STRINGDB
YRDC
Tdark
Novelty: 0.01240103
Score: 0.8
Data Source: STRINGDB
SLC6A2
Tclin
Family: Transporter
Novelty: 0.00093735
Score: 0.766
Data Source: STRINGDB
RPS13
Tbio
Novelty: 0.0019983
Score: 0.758
Data Source: STRINGDB
RAD23B
Tbio
Novelty: 0.00672104
Score: 0.752
Data Source: STRINGDB
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
Score: 0.713
Data Source: STRINGDB
SLC5A1
Tclin
Family: Transporter
Novelty: 0.00113611
Score: 0.644
Data Source: STRINGDB
SLC22A3
Tchem
Family: Transporter
Novelty: 0.00590004
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.87

PubMed score by year
PubTator Score  3.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer