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Tbio
SORL1
Sortilin-related receptor

Protein Classes
Protein Summary
Description
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260197
  • ENSP00000260197
  • ENSG00000137642

Symbol
  • C11orf32
  • LR11
  • LRP9
  • SORLA
  • gp250
  • SorLA-1
  • C11orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
kinase perturbation
0.99
gene perturbation
0.97
protein domain
0.97
PubMedID
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.54   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.54   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
3
4
92.3
smoking status measurement
2
2
2
90.9
6
1
0
1.3
88.6
family history of Alzheimer’s disease
2
1
0
3.9
79.3
alcohol use disorder measurement
2
1
1
6
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
92.3
smoking status measurement
2
90.9
0
1.3
88.6
family history of Alzheimer’s disease
0
3.9
79.3
alcohol use disorder measurement
1
6
29.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sortilin related receptor 1
VGNC:12811
451626
Mouse
MGI:1202296
20660
Dog
sortilin related receptor 1
VGNC:46663
479408
Horse
sortilin related receptor 1
VGNC:23452
100071572
Cow
sortilin related receptor 1
VGNC:35132
533166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sortilin related receptor 1
Mouse
Dog
sortilin related receptor 1
Horse
sortilin related receptor 1
Cow
sortilin related receptor 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92673-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
Alzheimers_University_of_Toronto
Inferred from Physical Interaction (IPI)
Alzheimers_University_of_Toronto
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (185)
1 – 10 of 185
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.999983262
p_ni: 0.000016738
Data Source: BioPlex
LRPAP1
Tbio
Novelty: 0.00214194
p_int: 0.99996748
p_ni: 0.00003252
Score: 0.514
Data Source: BioPlex,STRINGDB
ZNF354C
Tdark
Family: TF
Novelty: 0.09978239
p_int: 0.999913871
p_ni: 0.000086129
Data Source: BioPlex
SP6
Tbio
Family: TF
Novelty: 0.00201789
p_int: 0.999768284
p_ni: 0.000231716
Data Source: BioPlex
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.999634826
p_ni: 0.000365174
Data Source: BioPlex
TYW3
Tdark
Novelty: 0.15183348
p_int: 0.999633184
p_ni: 0.000366816
Data Source: BioPlex
ANKRD36B
Tdark
Novelty: 2.44907149
p_int: 0.999617317
p_ni: 0.000382683
Data Source: BioPlex
ZNF563
Tdark
Family: TF
Novelty: 5.34386694
p_int: 0.99942773
p_ni: 0.00057227
Data Source: BioPlex
ZNF224
Tbio
Family: TF
Novelty: 0.05381083
p_int: 0.999392332
p_ni: 0.000607668
Score: 0.228
Data Source: BioPlex,STRINGDB
FEZF1
Tbio
Family: TF
Novelty: 0.01942826
p_int: 0.999224241
p_ni: 0.000775759
Data Source: BioPlex
Publication Statistics
PubMed Score  298.54

PubMed score by year
PubTator Score  180.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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