You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AKAP1
A-kinase anchor protein 1, mitochondrial

Protein Summary
Description
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314126
  • ENSP00000314075
  • ENSG00000121057
  • ENST00000337714
  • ENSP00000337736
  • ENST00000481416
  • ENSP00000433212
  • ENST00000539273
  • ENSP00000443139
  • ENST00000571629
  • ENSP00000459968
  • ENST00000572557
  • ENSP00000459895
  • ENST00000621116
  • ENSP00000478212

Symbol
  • AKAP149
  • PRKA1
  • AKAP
  • PRKA1
  • AKAP84
  • TDRD17
  • AKAP121
  • AKAP149
  • D-AKAP1
  • PPP1R43
  • SAKAP84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.93
transcription factor perturbation
0.91
PubMedID
0.81
cellular component
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.37   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.37   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
2
3
83.8
2
2
1
1.2
75.2
Alopecia
1
2
2
74.6
puberty onset measurement
3
1
3
21.4
hair color
1
1
0
1.1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
83.8
1
1.2
75.2
Alopecia
2
74.6
puberty onset measurement
3
21.4
hair color
0
1.1
20.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 1
VGNC:6329
455150
Macaque
A-kinase anchoring protein 1
708500
Mouse
MGI:104729
11640
Rat
RGD:620826
114124
Dog
A-kinase anchoring protein 1
VGNC:37751
480567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 1
Macaque
A-kinase anchoring protein 1
Mouse
Rat
Dog
A-kinase anchoring protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92667-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (39)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Mitochondrial calcium ion transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Mitochondrial calcium ion transport
Transport of small molecules
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (114)
1 – 10 of 114
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.999942616
p_ni:  0.000057384
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.999913204
p_ni:  0.000086796
Score:  0.198
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999709318
p_ni:  0.000290682
p_wrong:  1e-9
Data Source:  BioPlex
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.998724479
p_ni:  0.001275521
Score:  0.638
Data Source:  BioPlex,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.994635083
p_ni:  0.005364917
Score:  0.973
Data Source:  BioPlex,Reactome,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.979414252
p_ni:  0.020585748
Score:  0.157
Data Source:  BioPlex,STRINGDB
PRSS37
Tdark
Family:  Enzyme
Novelty:  0.40482351
p_int:  0.901280943
p_ni:  0.098719056
Score:  0.189
Data Source:  BioPlex,STRINGDB
MTHFD1L
Tbio
Family:  Enzyme
Novelty:  0.01548353
p_int:  0.813191165
p_ni:  0.186787818
p_wrong:  0.000021016
Data Source:  BioPlex
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.774948479
p_ni:  0.225051325
p_wrong:  1.97e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  227.37

PubMed score by year
PubTator Score  181.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: