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Tdark
MRPS31
28S ribosomal protein S31, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323563
  • ENSP00000315397
  • ENSG00000102738

Symbol
  • IMOGN38
  • S31mt
  • IMOGN38
  • MRP-S31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.98
interacting protein
0.95
transcription factor binding site profile
0.92
histone modification site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999808696
p_ni:  0.000191304
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.999229302
p_ni:  0.000770698
Score:  0.995
Data Source:  BioPlex,STRINGDB
FAM177A1
Tdark
Novelty:  0.31314275
p_int:  0.999020158
p_ni:  0.000977978
p_wrong:  0.000001865
Data Source:  BioPlex
PTCD3
Tbio
Novelty:  0.12368434
p_int:  0.99846826
p_ni:  0.00153174
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.997731753
p_ni:  0.002268247
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.997041554
p_ni:  0.002958446
Score:  0.976
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.996319868
p_ni:  0.003680132
Score:  0.997
Data Source:  BioPlex,STRINGDB
CDK19
Tchem
Family:  Kinase
Novelty:  0.03132669
p_int:  0.995432046
p_ni:  0.004567954
Data Source:  BioPlex
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.994677515
p_ni:  0.005322485
Score:  0.912
Data Source:  BioPlex,STRINGDB
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.994244196
p_ni:  0.005755804
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
94.7
eosinophil percentage of leukocytes
2
2
2
83.8
monocyte percentage of leukocytes
2
1
2
83.1
red blood cell density measurement
2
2
2
81.9
mean corpuscular volume
2
2
2
79.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.7
eosinophil percentage of leukocytes
2
83.8
monocyte percentage of leukocytes
2
83.1
red blood cell density measurement
2
81.9
mean corpuscular volume
2
79.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S31
VGNC:5080
452552
Mouse
MGI:1913153
57312
Rat
RGD:1307668
290850
Dog
mitochondrial ribosomal protein S31
VGNC:43421
477294
Horse
mitochondrial ribosomal protein S31
VGNC:20366
100146458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S31
Mouse
Rat
Dog
mitochondrial ribosomal protein S31
Horse
mitochondrial ribosomal protein S31
Publication Statistics
PubMed Score 3.76
PubMed score by year
PubTator Score 1.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title