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Tbio
GTF3A
Transcription factor IIIA

Protein Summary
Description
Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the puri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000640289
  • ENSP00000491190
  • ENSG00000122034

Symbol
  • AP2
  • TFIIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.97
transcription factor perturbation
0.91
transcription factor binding site profile
0.83
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
GTF3C1
Tbio
Novelty:  0.00580303
Score:  0.985
Data Source:  STRINGDB
BDP1
Tbio
Novelty:  0.00497963
Score:  0.972
Data Source:  Reactome,STRINGDB
BRF1
Tbio
Novelty:  0.03174992
Score:  0.965
Data Source:  Reactome,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
Score:  0.96
Data Source:  STRINGDB
GTF3C2
Tdark
Novelty:  0.1827844
Score:  0.95
Data Source:  STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
Score:  0.946
Data Source:  STRINGDB
GTF3C5
Tdark
Novelty:  0.38618595
Score:  0.942
Data Source:  STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
Score:  0.942
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.939
Data Source:  STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
6
9
90.1
red blood cell distribution width
2
2
2
63.2
comparative body size at age 10, self-reported
1
1
1
13.1
body height
1
1
1
11.9
age at first sexual intercourse measurement
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
90.1
red blood cell distribution width
2
63.2
comparative body size at age 10, self-reported
1
13.1
body height
1
11.9
age at first sexual intercourse measurement
1
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIA
VGNC:8879
467243
Macaque
general transcription factor IIIA
710492
Mouse
MGI:1913846
66596
Rat
RGD:619746
246299
Dog
general transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIA
Macaque
general transcription factor IIIA
Mouse
Rat
Dog
general transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662]
Publication Statistics
PubMed Score 435.17
PubMed score by year
PubTator Score 68.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title