GTF3A
Transcription factor IIIA
Protein Summary
Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the puri ...more
- ENST00000640289
- ENSP00000491190
- ENSG00000122034
- AP2
- TFIIIA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.97 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.83 | ||
PubMedID | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 435.17 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 435.17 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (116)
Nearest Tclin Targets
Pathways (36)
Reactome (5)
PathwayCommons (1)
WikiPathways (30)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | RNA Polymerase III Abortive And Retractive Initiation | ||||
Reactome | RNA Polymerase III Transcription | ||||
Reactome | RNA Polymerase III Transcription Initiation | ||||
Reactome | RNA Polymerase III Transcription Initiation From Type 1 Promoter | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
RNA Polymerase III Abortive And Retractive Initiation | ||||
RNA Polymerase III Transcription | ||||
RNA Polymerase III Transcription Initiation | ||||
RNA Polymerase III Transcription Initiation From Type 1 Promoter | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (4)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 8 | 6 | 9 | 90.1 | |||||
red blood cell distribution width | 2 | 2 | 2 | 63.2 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 13.1 | |||||
body height | 1 | 1 | 1 | 11.9 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 8.6 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 9 | 90.1 | |||||
red blood cell distribution width | 2 | 63.2 | |||||
comparative body size at age 10, self-reported | 1 | 13.1 | |||||
body height | 1 | 11.9 | |||||
age at first sexual intercourse measurement | 1 | 8.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | general transcription factor IIIA | VGNC:8879 | 467243 | |||||
Macaque | general transcription factor IIIA | 710492 | ||||||
Mouse | MGI:1913846 | 66596 | ||||||
Rat | RGD:619746 | 246299 | ||||||
Dog | general transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | general transcription factor IIIA | |||||
Macaque | general transcription factor IIIA | |||||
Mouse | ||||||
Rat | ||||||
Dog | general transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662] | |||||
Publication Statistics
PubMed Score 435.17
PubMed score by year
PubTator Score 68.03
PubTator score by year
Related Publications
Text Mined References (15)
Items per page:
0 of 0
PMID | Year | Title |
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