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Tchem
LPAR1
Lysophosphatidic acid receptor 1

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (Pub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358883
  • ENSP00000351755
  • ENSG00000198121
  • ENST00000374430
  • ENSP00000363552
  • ENST00000374431
  • ENSP00000363553

Symbol
  • EDG2
  • LPA1
  • EDG2
  • LPA1
  • VZG1
  • GPR26
  • edg-2
  • vzg-1
  • Gpcr26
  • Mrec1.3
  • rec.1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.96
kinase perturbation
0.88
PubMedID
0.88
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.45   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.45   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 140
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (140)
1 – 10 of 140
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
94
eosinophil percentage of leukocytes
2
2
2
92.6
central corneal thickness
3
2
0
2.9
85.6
body height
3
3
3
76
sum of eosinophil and basophil counts
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94
eosinophil percentage of leukocytes
2
92.6
central corneal thickness
0
2.9
85.6
body height
3
76
sum of eosinophil and basophil counts
1
68.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 1
VGNC:4780
464655
Macaque
lysophosphatidic acid receptor 1
709208
Mouse
MGI:108429
14745
Rat
RGD:620563
116744
Dog
lysophosphatidic acid receptor 1
VGNC:42742
474800
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 1
Macaque
lysophosphatidic acid receptor 1
Mouse
Rat
Dog
lysophosphatidic acid receptor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92633-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (517)
1 – 10 of 517
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  1
Score:  0.543
Data Source:  BioPlex,STRINGDB
TYRO3
Tchem
Family:  Kinase
Novelty:  0.00233016
p_int:  0.999999296
p_ni:  7.03e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
TESC
Tbio
Novelty:  0.01977956
p_int:  0.999995497
p_ni:  6.59e-7
p_wrong:  0.000003844
Score:  0.516
Data Source:  BioPlex,STRINGDB
CERS4
Tbio
Family:  TF
Novelty:  0.01741762
p_int:  0.999983307
p_ni:  0.000016679
p_wrong:  1.3e-8
Score:  0.563
Data Source:  BioPlex,STRINGDB
ENPP4
Tbio
Family:  Enzyme
Novelty:  0.09897251
p_int:  0.999959374
p_ni:  0.000040616
p_wrong:  1e-8
Score:  0.239
Data Source:  BioPlex,STRINGDB
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
p_int:  0.999921045
p_ni:  0.000078955
Score:  0.225
Data Source:  BioPlex,STRINGDB
TPCN1
Tchem
Family:  IC
Novelty:  0.003844
p_int:  0.999915366
p_ni:  0.000084633
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
p_int:  0.999799842
p_ni:  0.000200147
p_wrong:  1e-8
Score:  0.176
Data Source:  BioPlex,STRINGDB
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.999475895
p_ni:  0.000524095
p_wrong:  1e-8
Data Source:  BioPlex
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.999439639
p_ni:  0.000560355
p_wrong:  5e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  356.45

PubMed score by year
PubTator Score  199.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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