You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

Protein Summary
Description
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344096
  • ENSP00000342105
  • ENSG00000127334
  • ENST00000393555
  • ENSP00000377186
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.97
virus perturbation
0.97
microRNA
0.91
small molecule
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.91   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.91   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Chemical Tool
N-(2-((2-aminoethyl)(methyl)amino)-5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)phenyl)acetamide
image for N-(2-((2-aminoethyl)(methyl)amino)-5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)phenyl)acetamide
Details:
  • ChEBI: 143115
  • Provider: UNC-CH
  • Activity: 160 nM
  • Selectivity: 0.042
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (140)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Phosphorylation
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (59)
1 – 10 of 59
RTN1
Tbio
Novelty: 0.01828064
p_int: 0.999999972
p_ni: 9e-9
p_wrong: 2e-8
Score: 0.31
Data Source: BioPlex,STRINGDB
MAPK4
Tbio
Family: Kinase
Novelty: 0.0223868
p_int: 0.999806995
p_ni: 0.000190728
p_wrong: 0.000002277
Data Source: BioPlex
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.98868515
p_ni: 0.01131485
Score: 0.22
Data Source: BioPlex,STRINGDB
BIRC6
Tbio
Novelty: 0.01187953
p_int: 0.89897844
p_ni: 0.10102156
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.986
Data Source: Reactome,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.949
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.946
Data Source: Reactome,STRINGDB
MDM4
Tchem
Novelty: 0.00321558
Score: 0.924
Data Source: STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
Score: 0.909
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.91

PubMed score by year
PubTator Score  38.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer